This paper commences with an overview of global social work ethics’ fundamental principles and the prevalent international framework, followed by tracing the evolution of China’s social work ethics and its indigenous characteristics. Through meticulous examination of core ethical elements in international social work and in-depth scrutiny of the integration between traditional Chinese ethics and social work ethics, the study illuminates similarities and differences between Eastern and Western ethical paradigms in social work. Leveraging comparative analysis of exemplar cross-cultural social work cases, the research explores how social work ethics can adapt to local contexts during cross-cultural integration, proposing strategies to address challenges and chart future directions. The findings significantly contribute to refining China’s social work ethical system and enhancing service quality within the global context.