In the context of educational modernization, the cultivation of innovation and entrepreneurship has become a key direction of high_x005fer education. As an essential quality for the innovation and entrepreneurship ability of college students, information literacy is often overlooked in the process of carrying out innovation and entrepreneurship education, leading to insufficient practical effects of overall innovation and entrepreneurship education. In the new era of higher education, in order to cultivate innovation and entrepreneurship abilities, it is necessary to organically integrate information literacy into the teaching of innovation and entrepreneurship ability cultivation, improve the overall quality of innovation and entrepreneurship education, and continuously improve the level of innovation and entrepreneurship education. Therefore, this article systematically studies the information literacy of college students from the perspective of cultivating innovation and entrepreneurship abilities, explores effective strategies to improve their information literacy in the innovation and entrepreneurship education environment, and implements the fundamental educational task of cultivating morality and talent.