Relying on the unique local ecological environment and rich tourism resources, Guizhou Province(located in the Southwest of China) adheres to the concept of sustainable development, and the development of the tourism industry has gainning remarkable results, bringing considerable economic benefits. Driven by economic development and environmental protection, ecotourism and tourism development in Guizhou Province are interpenetrated. The purpose of this paper is to discover the problems existing in the development of ecotourism and tourism economy in Guizhou Province, to find a long-term path to further integration of the two, to comprehensively enhance the competitive strengh of ecotourism, and to achieve the coordinated development of economy, society and environment.