A numerical investigation utilizing water as the working fluid was conducted on a 2D closed loop pulsating heat pipe (CLPHP) using the CFD software AnsysFluent19.0. This computational fluid dynamics (CFD) investigation explores three instances where there is a consistent input of heat flux in the evaporator region, but the temperatures in the condenser region differ across the cases. In each case, the condenser temperatures are set at 10 ℃, 20 ℃, and 30 ℃ respectively. The transient simulation is conducted with uniform time steps of 10 s. Generally, the heat rejection medium operated at a lower temperature performs better than at a higher temperature. In this CFD study the thermal resistances gets decreased with the decreasing value of condenser temperatures and the deviation of 35.31% of thermal resistance gets decreased with the condenser region operated at the temperature of 10 ℃.