The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

To investigate the effect of the location of vacuum insulation panels on the thermal insulation performance of marine reefer containers, a 20^ft mechanical refrigeration reefer container was employed in this paper, and the physical and mathematical models of three kinds of envelopes composed of vacuum insulation panels (VIP) and polyurethane foam (PU) were numerically established. The heat transfer of three types of envelopes under unsteady conditions was simulated. In order to be able to analyze theoretically, the Rasch transform is used to analyze the thermal inertia magnitude by calculating the thermal transfer response frequency and the thermal transfer response coefficient for each model, and the results are compared with the simulation results. The results implied that the insulation performance of VIP external insulation is the best. The delay times of each model obtained from the simulation results are 0.81 h, 1.45 h, 2.03 h, and 2.24 h, while the attenuation ratios are 8.93, 20.39, 20.62, and 21.78, respectively; the delay times calculated from the theoretical analysis are 0.78 h, 1.43 h, 1.99 h, and 2.20 h, respectively; and the attenuation ratios are 8.84, 20.31, 20.55, and 21.72, respectively. The carbon reduction effect of VIP external insulation is also the best. The most considerable carbon reduction is 3.65894 kg less than the traditional PU structure within 24 h. The research has a guiding significance for the research and progress of the new generation of energy-saving reefer containers and the insulation design of the envelope of refrigerated transportation equipment.

A gradually detailed geophysical investigation took place on Ancient Marina territory. In that area was extended Ancient Tritaea, according to responsible Archaeological Services. The first approach had been attempted since 1988 by applied electric mapping based on a twin-probe array. Later, the survey extended to the peripheral zone under the relative request from the 6th Archaeological Antiquity. A new approach was implemented by combining three different geophysical techniques, like electrical mapping, total intensity, and vertical gradient. These were applied on discrete geophysical grids. Electric mapping tried to separate the area into low and high-interest subareas according to soil resistance allocation. That technique detected enough geometrical characteristics, which worked as the main lever for the application of two other geophysical techniques. The other two techniques would be to certify the existence of geometrical characteristics, which divorced them from geological findings. Magnetic methods were characterized as a rapid technique with greater sensitivity in relation to electric mapping. Also, vertical gradient focuses on the horizontal extension of buried remains. Processing of magnetic measurements (total and vertical) certified the results from electric mapping. Also, both of the techniques confirmed the existence of human activity results, which were presented as a cross-section of two perpendicular parts. The new survey results showed that the new findings related to results from the previous approach. Geophysical research in that area is continuing.

This study aims to investigate the enhancement in electrical efficiency of a polycrystalline photovoltaic (PV) module. The performance of a PV module primarily depends upon environmental factors like temperature, irradiance, etc. Mainly, the PV module performance depends upon the panel temperature. The performance of the PV module has an inverse relationship with temperature. The open circuit voltage of a module decreases with the increase in temperature, which consequently leads to the reduction in maximum power, efficiency, and fill factor. This study investigates the increase in the efficiency of the PV module by lowering the panel temperature with the help of water channel cooling and water-channel accompanied with forced convection. The two arrangements, namely, multi-inlet outlet and serpentine, are used to decrease the temperature of the polycrystalline PV module. Copper tubes in the form of the above arrangements are employed at the back surface of the panel. The results demonstrate that the combined technique is more efficient than the simple water-channel cooling technique owing to multi-heat dissipation and effective heat transfer, and it is concluded that the multi-inlet outlet cooling technique is more efficient than the serpentine cooling technique, which is attributed to uniform cooling over the surface and lesser pressure losses.

Optimizing Storage Location Assignment (SLA) is essential for improving warehouse operations, reducing operational costs, travel distances and picking times. The effectiveness of the optimization process should be evaluated. This study introduces a novel, generalized objective function tailored to optimize SLA through integration with a Genetic Algorithm. The method incorporates key parameters such as item order frequency, storage grouping, and proximity of items frequently ordered together. Using simulation tools, this research models a picker-to-part system in a warehouse environment characterized by complex storage constraints, varying item demands and family-grouping criteria. The study explores four scenarios with distinct parameter weightings to analyze their impact on SLA. Contrary to other research that focuses on frequency-based assignment, this article presents a novel framework for designing SLA using key parameters. The study proves that it is advantageous to deviate from a frequency-based assignment, as considering other key parameters to determine the layout can lead to more favorable operations. The findings reveal that adjusting the parameter weightings enables effective SLA customization based on warehouse operational characteristics. Scenario-based analyses demonstrated significant reductions in travel distances during order picking tasks, particularly in scenarios prioritizing ordered-together proximity and group storage. Visual layouts and picking route evaluations highlighted the benefits of balancing frequency-based arrangements with grouping strategies. The study validates the utility of a tailored generalized objective function for SLA optimization. Scenario-based evaluations underscore the importance of fine-tuning SLA strategies to align with specific operational demands, paving the way for more efficient order picking and overall warehouse management.

A Detailed geophysical investigation was conducted on Knossos territory of Crete Island. Main scope was the detection of underground archaeological settlements. Geophysical prospecting applied by an experienced geophysical team. According to area dimensions in relation to geological and structural conditions, the team designed specific geophysical techniques, by adopted non-catastrophic methods. Three different types of geophysical techniques performed gradually. Geophysical investigation consisted of the application of geoelectric mapping and geomagnetic prospecting. Electric mapping focusses on recording soil resistance distribution. Geomagnetic survey was performed by using two different types of magnetometers. Firstly, recorded distribution of geomagnetic intensity and secondly alteration of vertical gradient. Measured stations laid along the south-north axis with intervals equal to one meter. Both magnetometers were adjusted on a quiet magnetic station. Values were stored in files readable by geophysical interpretation software in XYZ format. Oasis Montaj was adopted for interpretation of measured physical properties distribution. Interpretation results were illustrated as color scale maps. Further processing applied on magnetic measurements. Results are confirmed by overlaying results from three different techniques. Geoelectric mapping contributed to detection of a few archaeological targets. Most of them were recorded by geomagnetic technique. Total intensity aimed to report the existence of magnetized bodies. Vertical gradient detected subsurface targets with clearly geometrical characteristics.