To study the environment of the Kipushi mining locality (LMK), the evolution of its landscape was observed using Landsat images from 2000 to 2020. The evolution of the landscape was generally modified by the unplanned expansion of human settlements, agricultural areas, associated with the increase in firewood collection, carbonization, and exploitation of quarry materials. The problem is that this area has never benefited from change detection studies and the LMK area is very heterogeneous. The objective of the study is to evaluate the performance of classification algorithms and apply change detection to highlight the degradation of the LMK. The first approach concerned the classifications based on the stacking of the analyzed Landsat image bands of 2000 and 2020. And the second method performed the classifications on neo-images derived from concatenations of the spectral indices: Normalized Difference Vegetation Index (NDVI), Normalized Difference Building Index (NDBI) and Normalized Difference Water Index (NDWI). In both cases, the study comparatively examined the performance of five variants of classification algorithms, namely, Maximum Likelihood (ML), Minimum Distance (MD), Neural Network (NN), Parallelepiped (Para) and Spectral Angle Mapper (SAM). The results of the controlled classifications on the stacking of Landsat image bands from 2000 and 2020 were less consistent than those obtained with the index concatenation approach. The Para and DM classification algorithms were less efficient. With their respective Kappa scores ranging from 0.27 (2000 image) to 0.43 (2020 image) for Para and from 0.64 (2000 image) to 0.84 (2020 image) for DM. The results of the SAM classifier were satisfactory for the Kappa score of 0.83 (2000) and 0.88 (2020). The ML and NN were more suitable for the study area. Their respective Kappa scores ranged between 0.91 (image 2000) and 0.99 (image 2020) for the LM algorithm and between 0.95 (image 2000) and 0.96 (image 2020) for the NN algorithm.