Sanitation challenges are growing at unprecedented rates in the Middle East and North Africa (MENA) region, specifically in the country of Jordan, where more adversities are faced in the provision of inclusive and sustainable sanitation for marginalized communities. The overloaded water supply systems, strained by high population density in the face of political instability manifests itself in poor public health. How countries in the MENA region plan to handle these problems and improve the sanitation infrastructure is the starting point for this work. We aim to develop a comprehensive and multidisciplinary framework between stakeholders, aligned with the Sustainable Development Goals (SDGs), with a specific emphasis on SDG 6, for providing feasible, community-oriented approaches to sanitation issues in disenfranchised communities in Jordan through the Initiative Sanitation and Hygiene Networking in Jordanian Poverty Pockets (ISNJO) project. The findings will be used to formulate strategic guidelines and inform the development and subsequent initiation of innovative and multidisciplinary initiatives to tackle the sanitation and water scarcity challenges at hand.