The Cu_2–xSe nanoparticles were synthesized by high temperature pyrolysis, modified with aminated polyethylene glycol in aqueous solution and loaded with compound 2,2′–azobis[2–(2–imidazolin–2–yl)propane] dihydrochloride (AIPH). The obtained nanomaterials can induce photothermal effect and use heat to promote the generation of toxic AIPH radicals under the irradiation of near-infrared laser (808 nm), which can effectively kill cancer cells. A series of in vitro experiments can preliminarily prove that Cu_2–xSe–AIPH nanomaterials have strong photothermal conversion ability, good biocompatibility and anticancer properties.

This study explores the determinants of political participation among Thai youth, focusing on the roles of political interest, knowledge, and efficacy. Employing stratified random sampling, data were collected from 191 university students in Bangkok. Structural Equation Modeling (SEM) via Smart PLS was utilized to test hypotheses regarding the direct and mediating effects of political interest and knowledge on participation, highlighting the mediating role of political efficacy. The findings indicate that political efficacy significantly enhances participation, while political interest boosts knowledge significantly but does not directly influence efficacy. Furthermore, political knowledge positively affects efficacy but not participation directly. Notably, the indirect effects of political interest on participation through efficacy alone are insignificant, but the pathways from interest to participation through both knowledge and efficacy, and from knowledge to participation through efficacy, are significant. These results elucidate the complex interactions between political interest, knowledge, and efficacy in shaping the political engagement of Thai youth.