Instant and accurate evaluation of drug resistance in tumors before and during chemotherapy is important for patients with advanced colon cancer and is beneficial for prolonging their progression-free survival time. Here, the possible biomarkers that reflect the drug resistance of colon cancer were investigated using proton magnetic resonance spectroscopy (1H-MRS) in vivo. SW480[5-fluorouracil(5-FU)-responsive] and SW480/5-FU (5-FU-resistant) xenograft models were generated and subjected to in vivo 1H-MRS examinations when the maximum tumor diameter reached 1–1.5 cm. The areas under the peaks for metabolites, including choline (Cho), lactate (Lac), glutamine/glutamate (Glx), and myoinositol (Ins)/creatine (Cr) in the tumors, were analyzed between two groups. The resistancerelated protein expression, cell morphology, necrosis, apoptosis, and cell survival of these tumor specimens were assessed. The content for tCho, Lac, Glx, and Ins/Cr in the tumors of the SW480 group was significantly lower than that of the SW480/5-FU group (p < 0.05). While there was no significant difference in the degree of necrosis and apoptosis rate of tumor cells between the two groups (p > 0.05), the tumor cells of the SW480/5-FU showed a higher cell density and larger nuclei. The expression levels of resistance-related proteins (P-gp, MPR1, PKC) in the SW480 group were lower than those in the SW480/5-FU group (p < 0.01). The survival rate of 5-FU-resistant colon cancer cells was significantly higher than that of 5-FUresponsive ones at 5-FU concentrations greater than 2.5 μg/mL (p < 0.05). These results suggest that alterations in tCho, Lac, Glx1, Glx2, and Ins/Cr detected by 1H-MRS may be used for monitoring tumor resistance to 5-FU in vivo.

Considering the need to adopt more sustainable agricultural systems, it is important that sweet potato breeding programs seek to increase not only root productivity, but also the productivity and quality of branches for silage production. The objective was to evaluate the genetic divergence and the importance of traits associated with the production and quality of branch silage in sweet potato genotypes. The experiment was conducted on the JK Campus of the Federal University of Vales do Jequitinhonha and Mucuri Valleys in a randomized block design with 12 treatments and four repetitions. Twelve characteristics of branches and silage were evaluated. There was genetic variability between the genotypes, making it possible to select parents divergent for future breeding programs for silage production. The genotypes BD-54 and BD-31TO were the most divergent in relation to the others, being indicated its use in crossbreeding aiming the improvement of the culture for silage, once the high performance per se of all genotypes evaluated has already been verified in previous works. The characteristics Na, TDN and NDF were those that most contributed to the divergence.

Six Sigma is an organized and systematic method for strategic process improvement that relies on statistical and scientific methods to reduce the defect rates and achieve significant quality up-gradation. Six Sigma is also a business philosophy to improve customer satisfaction, a tool for eliminating process variation and errors and a metric of world class companies allowing for process comparisons. Six Sigma is one of the most effective advanced improvement strategies which has direct impact on operational excellence of an organization. Six Sigma may also be defined as the powerful business strategies, which have helped to improve quality initiatives in many industries around the world. With the use of Six Sigma in casting industries, rejection rate is reduced, customer satisfaction is improved and financial benefits also increased. Six Sigma management uses statistical process control to relentlessly and rigorously pursue the reduction of variation in all critical processes to achieve continuous and breakthrough improvements that impact the bottom-line and/or top-line of the organization and increase customer satisfaction. In this paper author reviewed some of the significant previous published papers and focused on the general overview of publication in casting industries.

In today's competitive and complex business environment, achieving business excellence requires a combination of effective methodologies and strong leadership to drive and sustain organizational transformation. Lean Six Sigma (LSS), a proven methodology for improving operational efficiency, relies on effective leadership for successful implementation and lasting impact. This study examines how the integration of Lean, Six Sigma, and Total Quality Management (TQM) shapes leadership strategies that enhance organizational agility, resilience, and responsiveness to market dynamics. It highlights the crucial role of leadership in fostering collaboration, optimizing resource utilization, and cultivating a culture of continuous improvement. The study introduces the Structured Lean Leadership Framework as a strategic tool to develop the leadership capabilities essential for LSS success, addressing challenges such as weak leadership commitment, resistance to change, and communication barriers. Through the application of the DMAIC framework, Key Performance Indicators (KPIs), and Voice of Customer (VOC) analysis, the research aligns LSS with business objectives, customer needs, and sustainability goals. Additionally, it explores how combining LSS with Agile methodologies can improve operational efficiency, governance, and innovation, helping organizations better navigate future challenges. This research offers valuable insights for executives, practitioners, and researchers, supporting leadership development, data-driven decision-making, and long-term value creation. Future studies should focus on validating the Structured Lean Leadership Framework, exploring Agile-LSS integration in regulated industries, and examining the impact of Industry 4.0 technologies on LSS and leadership.

In order to improve the quality and efficiency of heat treatment in welds of power stations, this paper summarizes the current situation of 600 MW supercritical power plant welding site heat treatment and puts forward the improved methods and measures accordingly. The heat treatment of welding holes in the construction site Play a certain guiding role.