Atomic interaction between mediator protein of human prostate cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use molecular dynamics (MD) approach based on Newton’s formalism to describe the destruction of PHPC via Fe/C720 Buckyballs-Statin with atomic accuracy. In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by universal force field (UFF) and DREIDING force-field to introduce their time evolution. The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27 Å to 2.96 Å after 10 ns. Physically, these interactions causing the destruction of the PHPC. Numerically, the volume of this biostructure enlarged from 665,276 Å3 to 737,143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry. Simulations indicated the volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.

The use of porous media to simplify the thermohydraulic of a nuclear reactor is the topic of recent research. As a case study, the rector of 200 kW installed at Missouri University of Science and Technology is modeled in this paper. To help this objective, a fundamental CFD examination was completed to supplement the neutronics investigation on the present reactor. Characteristics of thermal energy removal from a typical research reactor are modeled by numerical thermal transport in porous media. The neutron flux is modeled by the nodal expansion method. For the thermo-hydraulic part, a three-dimensional governing equation is solved by an iterative method to find the steady-state solution of fluid flow and temperature in loss of coolant condition where the heat produced in the reactor core is removed by free convection. The profiles of heat flux for various power levels are benchmarked. Pressure, temperature, and velocity contours in the power passage were assessed at 300 kW and 500 kW power levels. To reduce the computational cost, a porous media approach for the whole geometry was utilized. The numerical results agree with the experimental results. The developed model can be used for safety and reliability analysis for various loss of coolant accidents.

Based on the application of phase diagram calculation technique (CALPHAD), the Fe-Nd-B magnetic materials were investigated, and alloy design and microstructure evolution concerning. According to the thermodynamic database of Fe-Nd-B ternary system, the equilibrium solidification process of Fe78Nd15B7 alloy is simulated, and we explained well the reason of this experimental phenomenon by the metastable extension of the equilibrium phase diagram.

With the wide application of the Internet and smart systems, data centers (DCs) have become a hot spot of global concern. The energy saving for data centers is at the core of the related works. The thermal performance of a data center directly affects its total energy consumption, as cooling consumption accounts for nearly 50% of total energy consumption. Superior power distribution is a reliable method to improve the thermal performance of DCs. Therefore, analyzing the effects of different power distribution on thermal performance is a challenge for DCs. This paper analyzes the thermal performance numerically and experimentally in DCs with different power distribution. First, it uses Fluent simulate the temperature distribution and flow field distribution in the room, taking the cloud computing room as the research object. Then, it summarizes a formula based on the computing power distribution in a certain range by the numerical and experimental analysis. Finally, it calculates an optimal cooling power by analyzing the cooling power distribution. The results shows that it reduces the maximum temperature difference between the highest temperature of the cabinet from 5-7k to within 1.2k. In addition, the cooling energy consumption is reduced by more than 5%.

Small and medium-sized enterprises as the main body of Chinese enterprises should be an important driving force for China's economic development. However, the problems of salary management faced by small and medium-sized enterprises are increasingly hindering their own survival and development. Whether it is standing on the position of the enterprise or the workers, the pay problem is that they are more concerned about the problem, while the remuneration is also an indispensable modern means of competition and incentives. Salary management is not only indispensable content of enterprise human resources, but also the establishment of modern enterprise system, and optimization of the allocation of social resources requirements. Enterprise salary management operation flexibility or not, directly affect the production and operation management, which will affect the long-term development of enterprises. This paper analyzes the problems of salary management in small and medium-sized enterprises (SMEs), such as unreasonable pay system, lack of forward-looking management system, and so on, and analyzes and discusses their own countermeasures.

Instant and accurate evaluation of drug resistance in tumors before and during chemotherapy is important for patients with advanced colon cancer and is beneficial for prolonging their progression-free survival time. Here, the possible biomarkers that reflect the drug resistance of colon cancer were investigated using proton magnetic resonance spectroscopy (1H-MRS) in vivo. SW480[5-fluorouracil(5-FU)-responsive] and SW480/5-FU (5-FU-resistant) xenograft models were generated and subjected to in vivo 1H-MRS examinations when the maximum tumor diameter reached 1–1.5 cm. The areas under the peaks for metabolites, including choline (Cho), lactate (Lac), glutamine/glutamate (Glx), and myoinositol (Ins)/creatine (Cr) in the tumors, were analyzed between two groups. The resistancerelated protein expression, cell morphology, necrosis, apoptosis, and cell survival of these tumor specimens were assessed. The content for tCho, Lac, Glx, and Ins/Cr in the tumors of the SW480 group was significantly lower than that of the SW480/5-FU group (p < 0.05). While there was no significant difference in the degree of necrosis and apoptosis rate of tumor cells between the two groups (p > 0.05), the tumor cells of the SW480/5-FU showed a higher cell density and larger nuclei. The expression levels of resistance-related proteins (P-gp, MPR1, PKC) in the SW480 group were lower than those in the SW480/5-FU group (p < 0.01). The survival rate of 5-FU-resistant colon cancer cells was significantly higher than that of 5-FUresponsive ones at 5-FU concentrations greater than 2.5 μg/mL (p < 0.05). These results suggest that alterations in tCho, Lac, Glx1, Glx2, and Ins/Cr detected by 1H-MRS may be used for monitoring tumor resistance to 5-FU in vivo.