At present, many universities only focus on professional education for students in their education and teaching work, without strengthening the effective cultivation of students’ practical abilities. To address this issue, the role of innovation and entrepreneurship edu_x005fcation has gradually become prominent, and in education and teaching, it can help students improve their practical abilities. To cultivate the independent innovation and entrepreneurship abilities of college students, universities need to change their outdated educational ideas and adopt effective methods to carry out teaching, so that students can independently innovate and start businesses after graduation and achieve long-term development. Based on this, this article mainly analyzes the necessity of cultivating and enhancing the independent innovation and entrepreneurship ability of college students, and delves into strategies for cultivating and enhancing the ability, in order to enable students to continuously improve their independent innovation and entrepreneurship ability, have a broader development space, and indirectly promote social progress.