Instant and accurate evaluation of drug resistance in tumors before and during chemotherapy is important for patients with advanced colon cancer and is beneficial for prolonging their progression-free survival time. Here, the possible biomarkers that reflect the drug resistance of colon cancer were investigated using proton magnetic resonance spectroscopy (1H-MRS) in vivo. SW480[5-fluorouracil(5-FU)-responsive] and SW480/5-FU (5-FU-resistant) xenograft models were generated and subjected to in vivo 1H-MRS examinations when the maximum tumor diameter reached 1–1.5 cm. The areas under the peaks for metabolites, including choline (Cho), lactate (Lac), glutamine/glutamate (Glx), and myo-inositol (Ins)/creatine (Cr) in the tumors, were analyzed between two groups. The resistance-related protein expression, cell morphology, necrosis, apoptosis, and cell survival of these tumor specimens were assessed. The content for tCho, Lac, Glx, and Ins/Cr in the tumors of the SW480 group was significantly lower than that of the SW480/5-FU group (P < 0.05). While there was no significant difference in the degree of necrosis and apoptosis rate of tumor cells between the two groups (P > 0.05), the tumor cells of the SW480/5-FU showed a higher cell density and larger nuclei. The expression levels of resistance-related proteins (P-gp, MPR1, PKC) in the SW480 group were lower than those in the SW480/5-FU group (P < 0.01). The survival rate of 5-FU-resistant colon cancer cells was significantly higher than that of 5-FU-responsive ones at 5-FU concentrations greater than 2.5 μg/mL (P < 0.05). These results suggest that alterations in tCho, Lac, Glx1, Glx2, and Ins/Cr detected by 1H-MRS may be used for monitoring tumor resistance to 5-FU in vivo.

Disinformation can be defined as false information deliberately initiated to cause harm to a person, social group, organization, or country. Gendered disinformation then attacks or undermines people based on gender or weaponizes gendered narratives for political, social, or economic objectives. Gendered disinformation comes in different forms, such as harmful social media posts and graphics, sexual fabrications, and other forms of conspiracy theories. It is used in various situations and at different places. This research discussed the instances of gendered disinformation and harmful online narratives that are recognizable and visible. It sheds light on the potential direct and indirect impact on youth experiences. In this study, the young participants (aged 18–30) focused on the instances of the existing online narratives of gendered discrimination from Belgium, Greece, Latvia, Spain, and Türkiye. The research provided an initial analysis of what “gendered information and harmful online narratives” look like and some recommendations from youth perspectives on countering the issues. The study concluded that there is a need for more research, further harmonization of legal frameworks, and strengthened capacity to detect gendered disinformation, propaganda, and hate speech.

Fraudulence in cosmetic ingredients is becoming increasingly prevalent, alongside the rising demand and utilization of cosmetics within the populace. One of the whitening agents still utilized in cosmetics is mercury, present in forms such as mercury chloramide (HgNH₂Cl₂) and mercury chloride (HgCl₂). Prolonged mercury exposure can have adverse health effects. To address this issue, alternative mercury analysis methods in samples have been developed, including the utilization of silver nanoparticles amalgamated with sweet potato starch as a stabilizing agent. This paper aims to delve into the roles of silver nanoparticle AgNO₃ and sweet potato starch (as a stabilizer) as a sensor for mercury detection, which can be applied in cosmetic products. Detection of mercury utilizing nanoparticles is based on the Surface Plasmon Resonance phenomenon, which endows a high level of selectivity and sensitivity toward the presence of mercury metal ions. When interaction occurs between mercury metal and silver nanoparticles, the liquid undergoes a color change from yellowish-brown to transparent. This phenomenon arises from the oxidation of AgO (yellow) to Ag⁺ ions (transparent) by the mercury metal. Consequently, a silver nanoparticle sensor utilizing sweet potato starch as a stabilizing agent exhibits the potential to detect mercury metal within a substance with high efficacy.

UAVs, also known as unmanned aerial vehicles, have emerged as an efficient and flexible system for offering a rapid and cost-effective solution. In recent years, large-scale mapping using UAV photogrammetry has gained significant popularity and has been widely adopted in academia as well as the private sector. This study aims to investigate the technical aspects of this field, provide insights into the procedural steps involved, and present a case study conducted in Cesme, Izmir. The findings derived from the case study are thoroughly discussed, and the potential applications of UAV photogrammetry in large-scale mapping are examined. The study area is divided into 12 blocks. The flight plans and the distribution of ground control point (GCP) locations were determined based on these blocks. As a result of the data processing procedure, average GCP positional errors ranging from 1 to 18 cm have been obtained for the blocks.

Forests have ecological functions in water conservation, climate regulation, environmental purification, soil and water conservation, biodiversity protection and so on. Carrying out forest ecological quality assessment is of great significance to understand the global carbon cycle, energy cycle and climate change. Based on the introduction of the concept and research methods of forest ecological quality, this paper analyzes and summarizes the evaluation of forest ecological quality from three comprehensive indicators: forest biomass, forest productivity and forest structure. This paper focuses on the construction of evaluation index system, the acquisition of evaluation data and the estimation of key ecological parameters, discusses the main problems existing in the current forest ecological quality evaluation, and looks forward to its development prospects, including the unified standardization of evaluation indexes, high-quality data, the impact of forest living environment, the acquisition of forest level from multi-source remote sensing data, the application of vertical structural parameters and the interaction between forest ecological quality and ecological function.