With the rapid development of internet technology, online education has become an important trend in the education industry. Especially under the influence of the global COVID-19 epidemic, online teaching has been widely applied and promoted. However, there are also some problems with online teaching, such as a lack of realism and low student engagement. Therefore, exploring the integration of online and offline teaching models has become a hot research topic in the field of education. This article will analyze the reform strategy of integrating online and offline teaching in university mathematics courses, aiming to explore how to improve the teaching effectiveness of university mathematics courses and promote students' learning interest and ability through the integration of online and offline teaching.