The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

Helical deep hole drilling is a process frequently used in industrial applications to produce bores with a large length to diameter ratio. For better cooling and lubrication, the deep drilling oil is fed directly into the bore hole via two internal cooling channels. Due to the inaccessibility of the cutting area, experimental investigations that provide information on the actual machining and cooling behavior are difficult to carry out. In this paper, the distribution of the deep drilling oil is investigated both experimentally and simulatively and the results are evaluated. For the Computational Fluid Dynamics (CFD) simulation, two different turbulence models, i.e. the RANS k-ω-SST and hybrid SAS-SST model, are used and compared. Thereby, the actual used deep drilling oil is modelled instead of using fluid dynamic parameters of water, as is often the case. With the hybrid SAS-SST model, the flow could be analyzed much better than with the RANS k-ω-SST model and thus the processes that take place during helical deep drilling could be  simulated with realistic details. Both the experimental and the simulative results show that the deep drilling oil movement is almost exclusively generated by the tool rotation. At the tool’s cutting edges and in the flute, the flow velocity drops to zero for the most part, so that no efficient cooling and lubrication could take place there. In addition, cavitation bubbles form and implode, concluding in the assumption that the process heat is not adequately dissipated and the removal of chips is adversely affected, which in turn can affect the service life of the tool and the bore quality. The carried out investigations show that the application of CFD simulation is an important research instrument in machining technology and that there is still great potential in the area of tool and process optimization.

Numerical study of subcooled and saturated flow boiling in the curved and helically  coiled tubes in presence of phase change is one of the challenging area of CFD studies. In this paper, the CFD modeling of the nucleate and convective flow boiling in the small helically coiled tube at low vapor quality (up to the 18.93 percent) region is studied. A proper Eulerian-based mathematical model is used for interphase exchange forces and heat transfer between two phases in CFD modeling using Bulk boiling model. The results show that, the inner and the bottom wall of the helically coiled tube have the lowest and the highest heat transfer coefficient, respectively. The effect of change in coil diameter, helical pitch and tube diameter is investigated on the counters of vapor volume fraction. It is seen that at low vapor quality flows, the heat transfer coefficient is enhanced by decreasing in coil diameter, tube diameter and increasing in coil pitch of helically coiled tube. 

This study aims to investigate the enhancement in electrical efficiency of a polycrystalline photovoltaic (PV) module. The performance of a PV module primarily depends upon environmental factors like temperature, irradiance, etc. Mainly, the PV module performance depends upon the panel temperature. The performance of the PV module has an inverse relationship with temperature. The open circuit voltage of a module decreases with the increase in temperature, which consequently leads to the reduction in maximum power, efficiency, and fill factor. This study investigates the increase in the efficiency of the PV module by lowering the panel temperature with the help of water channel cooling and water-channel accompanied with forced convection. The two arrangements, namely, multi-inlet outlet and serpentine, are used to decrease the temperature of the polycrystalline PV module. Copper tubes in the form of the above arrangements are employed at the back surface of the panel. The results demonstrate that the combined technique is more efficient than the simple water-channel cooling technique owing to multi-heat dissipation and effective heat transfer, and it is concluded that the multi-inlet outlet cooling technique is more efficient than the serpentine cooling technique, which is attributed to uniform cooling over the surface and lesser pressure losses.