Technological innovation allows nations to produce sophisticated products more efficiently and at higher quality to increase exports. Countries that aim to produce and export sophisticated products can improve their economic complexity and lead to the country’s economic development. Hence, the study investigates the impact of technological innovation on economic complexity in South Africa. Technological innovation, exports, and manufactured products were used as variables to examine South Africa’s economic complexity index. The study employed the ARDL method to determine the relationship among the variables. The ARDL F-bounds test reflected the long-run cointegration among the selected variables. The study produced long-run positive estimates of technological innovation, exports, and manufactured products on economic complexity, however, manufactured products and exports were insignificant. Granger causality indicated unidirectional causality on economic complexity to manufactured products, exports to technological innovation, and a bi-directional causal effect from exports to economic complexity and technological innovation to economic complexity. The study recommends that South Africa focus on innovation, create more diversified and sophisticated products and processes, and promote more manufacturing firms, particularly Agri-processed products.