Climate change is an important factor that must be considered by designers of large infrastructure projects, with its effects anticipated throughout the infrastructure’s useful life. This paper discusses how engineers can address climate change adaptation in design holistically and sustainably. It offers a framework for adaptation in engineering design, focusing on risk evaluation over the entire life cycle. This approach avoids the extremes of inaction and designing for worst-case impacts that may not occur for several decades. The research reviews case studies and best practices from different parts of the world to demonstrate effective design solutions and adjustment measures that contribute to the sustainability and performance of infrastructure. The study highlights the need for interdisciplinary cooperation, sophisticated modeling approaches, and policy interventions for developing robust infrastructure systems.