The study aims to determine the development strategy of the Active Pharmaceutical Ingredients (API) industry in Indonesia to improve the resilience and competitiveness of the national pharmaceutical industry. The independence of the Indonesian pharmaceutical industry is low because the dependence on API imports is high, reaching 90-95%, thus threatening public health services and resilience. The method used is the Analytic Hierarchy Process (AHP), involving 13 experts from various sectors. The results of the study indicate that government involvement is the main priority in the development of the API industry, followed by the selection of API molecules and the development of partnerships. The proposed strategy is expected to accelerate the development of the local API industry to improve health resilience and reduce dependence on imports in the short term, while increasing the competitiveness of the Indonesian pharmaceutical industry in the medium to long term.