Application-oriented universities play a vital role in transporting application-oriented talent to regional industries and industries. In this paper, we discuss the significance and path of building experimental centers for economic management in application-oriented universities and highlight their role in student learning, school-business cooperation and social development. At the same time, it summarizes the problems found during the construction of the experimental center at case University and suggests some improvements, which serve as a reference for the construction of economic management experimental centers at similar universities.