Clinical/methodological problem: The identification of clinically significant prostate carcinomas while avoiding overdiagnosis of low-malignant tumors is a challenge in routine clinical practice. Standard radiologic procedures: Multiparametric magnetic resonance imaging (MRI) of the prostate acquired and interpreted according to PI-RADS (Prostate Imaging Reporting and Data System Guidelines) is accepted as a clinical standard among urologists and radiologists. Methodological innovations: The PI-RADS guidelines have been newly updated to version 2.1 and, in addition to more precise technical requirements, include individual changes in lesion assessment. Performance: The PI-RADS guidelines have become crucial in the standardization of multiparametric MRI of the prostate and provide templates for structured reporting, facilitating communication with the referring physician. Evaluation: The guidelines, now updated to version 2.1, represent a refinement of the widely used version 2.0. Many aspects of reporting have been clarified, but some previously known limitations remain and require further improvement of the guidelines in future versions.

Introduction: the presence of anti-CCP is an important prognostic tool for rheumatoid arthritis (RA), but its relationship with the activity of the disease and functional capacity is still being investigated. Objectives: to study the relationship between anti-CCP and the indices of disease activity, functional capacity and structural damage, by means of conventional radiography (CR) and magnetic resonance imaging (MRI), in stabilized RA. Methods: cross-sectional study of RA patients with one to 10 years of disease. The participants were subjected to clinical evaluation with anti-CCP screening. Disease activity was assessed by means of the Clinical Disease Activity Index (CDAI) and functional capacity by means of the Health Assessment Questionnaire (HAQ). CR was analyzed by the Sharp van der Heijde index (SmvH) and MRI by the Rheumatoid Arthritis Magnetic Resonance Image Scoring System (RAMRIS). Results: 56 patients were evaluated, with median (IIq) of 55 (47.5–60.0) years, 50 (89.3%) were female among whom 37 (66.1%) were positive for anti-CCP. The median (IIq) of CDAI, HAQ, SmvH and RAMRIS were 14.75 (5.42–24.97), 1.06 (0.28–1.75), 2 (0–8) and 15 (7–35), respectively. There was no association between anti-CCP and CDAI, HAQ, SmvH and RAMRIS. Conclusion: our results did not establish the association of anti-CCP with the severity of the disease. So far, we cannot corroborate the anti-CCP as a prognostic tool in RA established.

This paper considers the problems surrounding the implementation of road infrastructure plans in a policy perspective. As the main pillar of regional connectivity, road networks provide the link across national markets, foster strong and sustainable economic growth, help meeting people’s basic needs, and promote trade and competiveness. It is argued that planning, implementing, and managing good transportation infrastructures poses a series of challenges that require competence, good governance, and the availability of funds. Such problems become more complex when road projects encompass different states and become transnational. The regional dimension of connectivity involves both opportunities and risks; a cooperative attitude by all parties is viewed as the best ingredient to achieve a positive balance. Since most countries cannot still rely on domestic resources, the paper stresses the role of virtuous policies in directing capital flows from abroad towards the infrastructural projects of Southeast Asia.

Intra-regional trade serves as a key growth engine for East Asian economies. Accompanying the rapid growth of bilateral and intra-regional trade ties, the East Asian economies are becoming increasingly connected and interdependent. Infrastructure connectivity plays a crucial role in bridging different areas of the East Asian region and enabling them to reap the full socioeconomic benefits of economic cooperation and integration. Nevertheless, further improvement of infrastructure in the region faces major challenges due to the lack of effective mechanisms for coordination and dialogue on regional integration through funding infrastructure projects, as well as the serious trust deficit among member states that has arisen from the on-going territorial and historical disputes.

This paper uses a new cross-country cross-industry dataset on investment in tangible and intangible assets for 18 European countries and the US.  We set out a framework for measuring intangible investment and capital stocks and their effect on output, inputs and total factor productivity. The analysis provides evidence on the diffusion of intangible investment across Europe and the US over the years 2000-2013 and offers growth accounting evidence before and after the Great Recession in 2008-2009. Our major findings are the following. First, tangible investment fell massively during the Great Recession and has hardly recovered, whereas intangible investment has been relatively resilient and recovered fast in the US but lagged behind in the EU. Second, the sources of growth analysis including only national account intangibles (software, R&D, mineral exploration and artistic originals), suggest that capital deepening is the main driver of growth, with tangibles and intangibles accounting for 80% and 20% in the EU while both account for 50% in the US, over 2000-2013. Extending the asset boundary to the intangible assets not included in the national accounts (Corrado, Hulten and Sichel (2005)) makes capital deepening increase. The contribution of tangibles is reduced both in the EU and the US (60% and 40% respectively) while intangibles account for a larger share (40% in EU and 60% in the US). Then, our analysis shows that since the Great Recession, the slowdown in labour productivity growth has been driven by a decline in TFP growth with relatively a minor role for tangible and intangible capital. Finally, we document a significant correlation between stricter employment protection rules and less government investment in R&D, and a lower ratio of intangible to tangible investment.

The Belt and Road Initiative (BRI) aims to enhance connectivity and collaboration among 60 countries and beyond in Asia, Africa and Europe. Information and communications technology (ICT) is an indispensable component of the initiative, critical in providing fundamental communication channels for global financial transactions, trade exchanges and transport and energy connectivity, and socio cultural collaboration and scientific exchanges between people, organizations and countries along the BRI corridors. Previously constrained by infrastructure deficits in ICT, the Asia-Pacific region is accelerating its efforts to provide reliable and affordable broadband networks throughout the region, to contribute to successful implementation of the Sustainable Development Goals (SDG).

Within the BRI corridors, this study which has been undertaken as part of the research programme of the United Nations Economic and Social Commission for Asia and the Pacific (ESCAP) on promoting regional economic cooperation and integration, focuses on the China-Central Asia Corridor (China, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan), giving attention to the sub-region’s specific challenges, namely limited international transit opportunities and an increase in bandwidth requirements that is expected to grow exponentially, as the fourth industrial evolution centered on automation and artificial intelligence gathers momentum. The sub-region is characterized as highly dependent on the ease and costs of connecting to neighboring countries for transit, as many countries in the sub-region are landlocked developing countries (LLDC). Because of the geographical features and other factors, the development potential of Central Asia and its integration into globalization, continues to be stymied by insufficient international bandwidth and high transit costs to access international links. Therefore, improved ICT connectivity in Central Asia through the BRI corridor could result in improved availability and affordability of broadband networks and services in the sub-region.

For the purpose of this study, a gap analysis is the methodology that underpins the proposed topology for the China-Central Asia Corridor. The analysis included examining the current state of the optic infrastructure, such as existing and planned fiber-optic networks, existing Internet Exchange Points (IXPs) and international gateways. The study also identifies the key factors that determine the desired future state of infrastructure deployment for the BRI initiative. A topology that consists of connecting Almaty (Kazakhstan) and Urumqi (China), as core nodes, is proposed based on a partial mesh topology. Over and above this core finding, the study concludes that digital infrastructure connectivity has a tendency of lagging behind the rapid opportunities evolving, and the study therefore advocates for sub-regional and regional approaches, including the BRI and Asia-Pacific Information Superhighway (AP-IS) in further expanding regional broadband networks. A key recommendation of the study is co-deployment of broadband infrastructure along passive infrastructure, as an additional cost effective means of achieving fast and affordable broadband connectivity for all.