Taking the Indian students in Changsha Medical University as an example, this paper makes a quantitative study on the cross-cultural adaptation of Indian students from four aspects: the basic information of Indian students, the adaptation of Huxiang cultural life, the physical and mental adaptation, and the cultural differences. And then puts forward the corresponding strategies. It is found that the overall level of cross-cultural adaptation of Indian students in Changsha is good, and there is a correlation among Huxiang cultural life adaptation, physical and mental adaptation and cultural differences.