This study aims to combine the OBE concept with the ideology and politics of GIS spatial analysis course to cultivate high-quality talents with socialist core values. Firstly, the integration point of OBE concept and course ideology and politics was analyzed, and then the teaching system of GIS spatial analysis course based on OBE concept was designed, including teaching objectives, teaching contents, teaching methods and teaching evaluation system. The teaching system focuses on students’ participation and interaction, paid attention to students’ needs and learning characteristics, and at the same time integrates elements of ideological and political education to cultivate students’ socialist core values and vocational literacy. Finally, the learning process of students was tracked and analyzed by testing and evaluating students’ learning outcomes, while the teaching design was continuously improved and optimized by combining students’ feedback and improvement opinions. This study was of great significance for promoting the development of geographic information industry and the construction of GIS spatial analysis courses.