Objective: To explore the influencing factors of mental health and the mediating role of self-compassion between family cohesion and mental health. Method: Family Cohesion Scale, Symptom Checklist, and Self-compassion Scale were used to investigate 593 college students in Zhejiang Province. Result: Family Cohesion was negatively correlated with mental health and positively correlated with Self-compass- ion among college students; Self-compassion was negatively correlated with mental health. Self-compassion fully mediates the relationship between the two. Conclusion: The path of family cohesion is indirect, and strengthening Self-compassion education can improve the mental health level of college students.