Housing is one of the most significant components of sustainable development; hence, the need to come up with sustainable housing solutions. Nevertheless, the sales of houses are steadily falling due to the unaffordability of houses to many people. Based on the expanded community acceptance model, this research examines the relationships between sustainable housing and quality of life with the moderating factors of knowledge, technology, and innovation in Shenzhen. Additionally, it aims to delineate the principal dimensions influencing quality of life. The study employs purposive sampling and gathers data from residents of Shenzhen via a Tencent-distributed survey. Analysis was conducted using Smart Partial Least Squares (PLS) 4.0. Results indicate a positive correlation between economic sustainability in housing and quality of life. Contrarily, the social and environmental aspects exhibited negligible impacts on quality of life. Knowledge, technology, and innovation were identified as significant moderators in the correlation among all three sustainable housing dimensions and quality of life. The findings are anticipated to enhance understanding of the perceived impacts of sustainable housing on quality of life in Shenzhen and elucidate the role of knowledge, technology, and innovation in fostering this development.