This paper investigates the transformative role of Artificial Intelligence (AI) in enhancing infrastructure governance and economic outcomes. Through a bibliometric analysis spanning more than two decades of research from 2000 to 2024, the study examines global trends in AI applications within infrastructure projects. The analysis reveals significant research themes across diverse sectors, including urban development, healthcare, and environmental management, highlighting the broad relevance of AI technologies. In urban development, the integration of AI and Internet of Things (IoT) technologies is advancing smart city initiatives by improving infrastructure systems through enhanced data-driven decision-making. In healthcare, AI is revolutionizing patient care, improving diagnostic accuracy, and optimizing treatment strategies. Environmental management is benefiting from AI’s potential to monitor and conserve natural resources, contributing to sustainability and crisis management efforts. The study also explores the synergy between AI and blockchain technology, emphasizing its role in ensuring data security, transparency, and efficiency in various applications. The findings underscore the importance of a multidisciplinary approach in AI research and implementation, advocating for ethical considerations and strong governance frameworks to harness AI’s full potential responsibly.