This article scrutinizes the multifaceted challenges inherent in intergovernmental coordination across various sectors, with a particular emphasis on sustainable development and entrepreneurial activity within the Republic of Moldova. It argues that despite the existence of intergovernmental cooperation, it often manifests as deficient, contradictory, incomplete, and inefficient. Through a meticulous analysis, this study delineates the roles of pertinent authorities and institutions in fostering the sustainable development of entrepreneurial activities, identifying critical inter-institutional coordination issues and challenges. The discourse extends to examining institutional processes and the extent to which policies, laws, and international standards are implemented to nurture and sustain business activities. Moreover, the paper explores various strategies to cultivate responsible, transparent, and effective dialogue between institutions, thereby promoting innovative practices, expanding cooperation, and fostering partnerships with national and civil society organizations, including international bodies.