High-risk pregnancies are a global concern, with maternal and fetal well-being at the forefront of clinical care. Pregnancy’s three trimesters bring distinct changes to mothers and fetal development, impacting maternal health through hormonal, physical, and emotional shifts. Fetal well-being is influenced by organ development, nutrition, oxygenation, and environmental exposures. Effective management of high-risk pregnancies necessitates a specialized, multidisciplinary approach. To comprehend this integrated approach, a comparative literature analysis using Atlas.ti software is essential. Findings reveal key aspects vital to high-risk pregnancy care, including intervention effectiveness, case characteristics, regional variations, economic implications, psychosocial impacts, holistic care, longitudinal studies, cultural factors, technological influences, and educational strategies. These findings inform current clinical practices and drive further research. Integration of knowledge across multidisciplinary care teams is pivotal for enhancing care for high-risk pregnancies, promoting maternal and fetal well-being worldwide.