In order to explore how hygiene factors and motivational factors indirectly affect job satisfaction through teacher self-efficacy. Based on the two factor theory and Teacher Job Satisfaction Survey (TJS), this study analyzes how hygiene factors and motivational factors indirectly affect job satisfaction through teacher self-efficacy. The study collects valid questionnaires from 120 teachers and conducts mediation analysis using structural equation modeling. From the results, teacher self-efficacy had obvious mediating effects between hygiene factors and job satisfaction (β > 0.6, P < 0.001), as well as between motivational factors and job satisfaction (β > 0.6, P < 0.001). This discovery not only provides new perspectives and strategies for improving teacher job satisfaction, but also emphasizes the importance of enhancing teacher self-efficacy in improving job satisfaction. In addition, the study provides strong empirical evidence for education management departments and school leaders to formulate more effective teacher development policies and management measures, which has positive theoretical and practical significance for improving education quality and promoting education reform.