The use of geotechnologies combined with remote sensing has become increasingly essential and important for efficiently and economically understanding land use and land cover in specific regions. The objective of this study was to observe changes in agricultural activities, particularly agriculture/livestock farming, in the North Forest Zone of Pernambuco (Mata Norte), a political-administrative region where sugarcane cultivation has historically been the backbone of the local economy. The region’s sugarcane biomass also contributes to land use and land cover observations through remote sensing techniques applied to digital satellite images, such as those from Landsat-8, which was used in this study. This study was conducted through digital image processing, allowing the calculation of the Normalized Difference Vegetation Index (NDVI), the Soil-Adjusted Vegetation Index (SAVI), and the Leaf Area Index (LAI) to assess vegetation cover dynamics. The results revealed that sugarcane cultivation is the predominant agricultural and vegetation activity in Mata Norte. Livestock farming areas experienced a significant reduction over the observed decade, which, in turn, led to an increase in agricultural and forested areas. The most dynamic spatiotemporal behavior was observed in the expansion and reduction of livestock areas, a more significant change compared to sugarcane areas. Therefore, land use and land cover in this region are more closely tied to sugarcane cultivation than any other agricultural activity.