This study examined socio-economic factors affecting Micro, Small, and Medium Enterprises (MSME) e-commerce adoption, focusing on gender, income, and education. Using the 2022 National Socio-Economic Survey (Susenas) data, a logistic regression model was employed to analyze key determinants of e-commerce utilization. Additionally, an online survey of 550 MSMEs across 29 provinces was conducted to assess the impact of digitalization on business performance. In comparison, an offline study of 42 MSMEs with low digital adoption provided insights into the barriers hindering digital transformation. A natural experiment was conducted to evaluate the effectiveness of behavioral interventions in promoting the adoption of e-payments and e-commerce. The main contribution of this study lies in integrating large-scale national survey data with experimental approaches to provide a deeper understanding of digital adoption among MSMEs. Unlike previous studies focusing solely on socio-economic determinants, this research incorporated a digital nudging experiment to examine how targeted incentives influenced e-commerce participation. The findings revealed that digital transformation significantly enhanced MSME performance, particularly in turnover, product volume, customer base, and worker productivity. Socio-economic factors such as gender, household head status, and social media access significantly influenced digital adoption decisions. Behavioral nudging proved effective in increasing MSME participation in e-commerce. Although this study was limited to Susenas 2022 data and survey responses, it bridges a critical research gap by linking socio-economic factors with behavioral interventions in MSME digitalization. The findings offer key insights for policymakers in formulating evidence-based strategies to drive MSME digital transformation and e-commerce growth in Indonesia.