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The primary objective of this paper is to explore the impact of household policies in both Saudi Arabia and Nigeria towards achieving efficient and sustainable economic growth in the 21st century. Fundamentally, the objective of the study was sparked by the basic factors of comparison the importance of culture in international relations, challenges related to terrorism which impede adequate implementations of economic policies, trade facilitation and logistics to enhance economic growth and cross-border movement of goods and services. Systematic literature review (SLR) and content analysis (CA) were used as methodological approaches of the paper. The articles explored for review were accessed using visualization of similarities (VOS) by exploring different database such as: journals, core collection of Web of Science (WOS), peer review sources and library sources. The findings demonstrated that Saudi Arabia and Nigeria have different policies regarding households in achieving sustainable economic growth. On one hand, in Saudi Arabia, the focus is on the economic burden associated with chronic non-communicable diseases (NCDs) and the out-of-pocket spending among individuals diagnosed with these diseases. In addition, the study found that households with older and more educated members, an employed head of household, higher socioeconomic status, health insurance coverage, and urban residency had significantly higher out-of-pocket expenditure in achieving sustainable economic development. On the other hand, Nigeria’s policy is centered around trade liberalization and its impact on household welfare as an integral part of sustainable economic development. The policies implemented in Saudi Arabia and Nigeria have implications for the well-being of their citizens. In Saudi Arabia, the household policies have significantly impacted the quality of life (QoL) of households, particularly those with low income, large size, male-led, urban, and with elderly heads. In Nigeria, trade liberalization policies have mixed welfare implications for households in the aspects of real income, they also induce unemployment in key sectors, such as agriculture and industry. To mitigate negative effects, it is suggested that Saudi Arabia should effectively address chronic non-communicable diseases (NCDs) among the households while Nigeria should efficiently pursue trade liberalization on a sectorial basis, focusing on sectors that do not severely undermine household welfare.