Background: Multiple sclerosis is often a longitudinal disease continuum with an initial relapsing-remitting phase (RRMS) and later secondary progression (SPMS). Most currently approved therapies are not sufficiently effective in SPMS. Early detection of SPMS conversion is therefore critical for therapy selection. Important decision-making tools may include testing of partial cognitive performance and magnetic resonance imaging (MRI). Aim of the work: To demonstrate the importance of cognitive testing and MRI for the prediction and detection of SPMS conversion. Elaboration of strategies for follow-up and therapy management in practice, especially in outpatient care. Material and methods: Review based on an unsystematic literature search. Results: Standardized cognitive testing can be helpful for early SPMS diagnosis and facilitate progression assessment. Annual use of sensitive screening tests such as Symbol Digit Modalities Test (SDMT) and Brief Visual Memory Test-Revised (BVMT-R) or the Brief International Cognitive Assessment for MS (BICAMS) test battery is recommended. Persistent inflammatory activity on MRI in the first three years of disease and the presence of cortical lesions are predictive of SPMS conversion. Standardized MRI monitoring for features of progressive MS can support clinically and neurocognitively based suspicion of SPMS. Discussion: Interdisciplinary care of MS patients by clinically skilled neurologists, supported by neuropsychological testing and MRI, has a high value for SPMS prediction and diagnosis. The latter allows early conversion to appropriate therapies, as SPMS requires different interventions than RRMS. After drug switching, clinical, neuropsychological, and imaging vigilance allows stringent monitoring for neuroinflammatory and degenerative activity as well as treatment complications.

In higher education, mental health education is a complex task that involves many educational factors. From the perspective of psychological education, the basic tasks and value pursuits of university mental health education and curriculum ideological and political education are the same. Both are student-centered, providing a basic guarantee for the integration of the two. Currently, some universities are facing issues such as the need to clarify the concept of "psychological education", the trend towards value neutrality in mental health education, and the need to improve the quality of the psychological education team. In response to this situation, universities should integrate educational factors, provide clear value guidance, strengthen integrated education, improve the overall quality of the education team, continue to promote the ideological and political construction of psychological health education courses in universities, and achieve new breakthroughs.

The psychological health issues of college students are related to their growth and development. Only by implementing psychological health education and maintaining the physical and mental health development of college students can the quality and effectiveness of education be systematically improved. This article briefly analyzes the current situation of psychological health of local normal university students based on their psychological characteristics, and proposes methods for implementing scientific psychological health education for college students in combination with existing problems. The aim is to improve the effectiveness of talent cultivation and contribute to the development of local education.

Detailed record and analysis of a psychological crisis intervention and counseling process of college students during the "epidemic period": understanding the basic situation of students, problem analysis and judgment that students is in a state of psychological crisis, Analyzing five factors: students' family economic difficulties, stressful life events (their father died in a car accident), poor academic performance, lack of social support and staying at home during the epidemic, A targeted psychological crisis intervention, At the same time, to strengthen social support, Improving the family environment; Psychological counseling is conducted in a planned way, Set the phased psychological counseling goals and achieve them gradually, Focusing on the two topics of "meaning of life" and "self-denial", carry out psychological counseling, Finally, guide the students to clarify the meaning behind the psychological behavior, Put down the burden and go on lightly; In summary, this case has achieved a good guidance effect in the remission, breakthrough period and consolidation period, However, it is still worth paying attention to and discussing on the limitations of student psychological counseling and the boundary of daily counselors.