A The meaning of life is the purpose that defines a person’s existence based on a set of fundamental objectives that give meaning to life or not. Furthermore, not all individuals have a meaning in life, and it may be absent at some point or stage of life. Objective: To analyze Peruvian older adults’ socioeconomic factors and the meaning of life. Method: A descriptive, comparative, quantitative cross-sectional study was conducted. One thousand older adults were intentionally selected through quotas of 100 older adults in 10 localities in Arequipa, Peru. They were administered a survey validated with high levels of reliability on the meaning of life and socioeconomic factors. Results: A moderate level of meaning in life was found. Most older adults believe that increasing age decreases the purpose of living, and existential emptiness grows. Conclusions: Statistically significant differences (p < 0.05) were found between the meaning of life and the following socioeconomic factors: retirement, religion, educational level, cohabitation, marital status, income, and occupation. It is understood that older adults who scored higher on these factors indicate having meaning in life because they still fulfill the role of providers for the family economy, being util to their families compared to the majority who scored low, which indicates an absence of meaning of life leading to an increase existential void.