Rising fuel prices can affect driver behavior and thus the number of accidents, which is a key road safety issue. The aim of this paper was to assess and quantify the relationship between fuel prices (FP) and the number of road accidents in Europe. Content analysis of statistics from the countries was used to collect data, which were examined using Ramsey resets and Poisson distributions and then processed using negative binomial regression (NB), cluster analysis and visualization using contour plots. The results show that in Germany and Poland there is a statistically significant low negative correlation between fuel price and the number of traffic accidents, while in the Czech Republic and Denmark the relationship is weaker and statistically insignificant. In Iceland, no significant correlation was found. The contribution of this paper is to provide important insights that can be used in the development of transport policies and regulations to improve road safety. The main limitations include the difficulty of data collection, as many countries do not publish detailed statistics, and the low number of accidents in Iceland, which makes it impossible to perform a robust analysis for this country and may cause generalization of the results.