The benefits of information system users are an important topic in research on information system implementation in general as well as in hospital information systems in particular. The study is applying structural equation modelling in determining the factors affecting personal benefits of information system users, with the antecedents being the combination of perspectives, and the outcomes including individual user results of the system in hospitals. The study was conducted in two phases: a preliminary study and a formal study. The preliminary study aimed to adjust and supplement the observed variables to be suitable for the actual conditions in Vietnam by conducting a preliminary survey with a questionnaire involving 55 samples to assess the internal consistency reliability, convergent validity, and discriminant validity of the measurement scales. The formal quantitative study, which employed linear structural analysis with PLS-SEM, was conducted on 215 samples of individuals who had previously used information systems in several hospitals in Vietnam. The proposed model explained 80.6% of the variance in user engagement with the system and 50.6% of the variance in user satisfaction when using the information system. In more detail, for user benefits, it is worth noting that the strongest impact intensity belongs to information quality and the weakest belongs to support structure. In addition, confidence in one’s own abilities also has a high impact on user benefits when using the information system.