Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

This study analyzes the importance of strengthening the design of Indonesia’s maritime axis policy. This research uses a qualitative approach to systematically explain the dynamics and importance of strengthening world maritime policy, where the Nvivo 12 Plus tool is used to analyze data and answer the research questions posed. This research shows that Indonesia still has complex bureaucratic and institutional problems and aspects of political identity and leadership attitudes that require systematic and comprehensive improvement. Then, the draft for strengthening the maritime axis policy in Indonesia includes three policy recommendations: reformulating the focus of the maritime axis policy, comprehensive and coherent governance, and an integrated administrative framework, as well as improving the political identity and attitudes of leaders in public policy. Substantially, the relative failure of the Global Maritime Axis (GMA) policy, known as Joko Widodo’s concept of regulating the Indonesian government based on geographical location, was caused by the dominance of political factors and domestic bureaucratic problems. Apart from that, the lack of priority narratives in the maritime and development sectors means that the Indonesian government’s priorities are more oriented towards GMA infrastructure aspects and at the expense of other fundamental elements. This study encourages the Indonesian government to accelerate a more substantive GMA. However, this research needs to be expanded because the analysis results were only carried out through secondary data and focused on two important aspects of GMA. Therefore, further research is needed that explains the prospects for GMA policy in Indonesia in more detail.

In today’s manufacturing sector, high-quality materials that satisfy customers’ needs at a reduced cost are drawing attention in the global market. Also, as new applications are emerging, high-performance biocomposite products that complement them are required. The production of such high-performance materials requires suitable optimization techniques in the formulation/process design, not simply mixing natural fibre/filler, additives, and plastics, and characterization of the resulting biocomposites. However, a comprehensive review of the optimization strategies in biocomposite production intended for infrastructural applications is lacking. This study, therefore, presents a detailed discussion of the various optimization approaches, their strengths, and weaknesses in the formulation/process parameters of biocomposite manufacturing. The report explores the recent progress in optimization techniques in biocomposite material production to provide baseline information to researchers and industrialists in this field. Therefore, this review consolidates prior studies to explore new areas.

To achieve sustainable development, detailed planning, control and management of land cover changes that occur naturally or by human caused artificial factors, are essential. Urban managers and planners need a tool that represents them the information accurate, fast and in exact time. In this study, land use changes of 3 periods, 1994-2002, 2002-2009, 2009-2015 and predictions of 2009, 2015 and 2023 were assessed. In this paper, Maximum Likelihood method was used to classify the images, so that after evaluation of accuracy, amount of overall accuracy for images of 2013 was 85.55% and its Kappa coefficient was 80.03%. To predict land use changes, Markov-CA model was used after assessing the accuracy, and the amount of overall accuracy for 2009 was 82.57% and for 2015 was 93.865%. Then web GIS application was designed via map server application and evoked shape files through map file and open layers to browser environment and for design of appearance of website CSS, HTML and JavaScript languages were used. HTML is  responsible for creating the foundation and overall structure of webpage but beautifying and layout design on CSS. 

Gender inequality is a structural social problem, associated with history, culture, education, religion and politics, this difficulty occurs in all social institutions due to the heterogeneity of the structure in the sexual division of labor, socioeconomic inequality, inclusion and inequity in participation in the public space between men and women. Public policies and attitudes towards gender equality in Peruvian university students were analyzed according to socio-academic variables. A descriptive-comparative study, with a quantitative approach, and not experimental cross-sectional, involved 776 university students from a public and a private university in Peru, intentionally selected. Adaptive attitudes (57.9%) were found to tend to be sexist; Likewise, in the study dimensions, the same trend was found in the sociocultural and relational levels, while in the personal dimension students develop sexist attitudes (62.4%). It is concluded, attitudes towards gender equality are sexist reproduction that is influenced by the sociocultural environment of the family, this situation occurs to a greater extent in men, while female students present attitudes of equality in greater intensity to seek equity in the distribution of roles.

This research delves into the correlation between institutional quality and tourism development in a panel of nine Mediterranean countries within the European Union spanning from 1996 to 2021. The study gauges tourism development by examining tourist arrivals, while considering GDP growth rate, inflation, higher education, environmental quality, and trade as control variables representing factors influencing tourism. Institutional quality is measured through indicators such as regulatory quality, rule of law, and control of corruption. Utilizing Fully Modified Ordinary Least Square (FMOLS) and Dynamic Ordinary Least Squares (DOLS) models, the study aims to quantify the impact of these factors on tourism development. The findings indicate a positive relationship between institutional quality and tourism, shedding light on the pivotal role of institutions in tourism management and their influence on the sector. These results have implications for shaping national development strategies.