Subcutaneous (SC) drug delivery is one of the best routes of drug administration to patients over intravenous (IV) administration due to the ease of application and patient acceptance. The main limitation of using the SC route is administering larger volumes of drug, greater than 3–5 mL for therapeutic dosages. Wearable injectors on body devices are an attractive option for larger-volume drug delivery to patients. Thus, the need for a self-administration strategy at home is growing faster and is required for the next level of time-dependent and high-volume drug delivery. The advances in low-cost, connected on-body delivery systems hold great opportunity for novel ways of delivering home-based drug therapy in the future.
Disease epidemics may spread quickly and easily throughout nations and continents in our current global environment, having a devastating effect on public health and the world economy. There are over 513 million people worldwide who have been infected, and more than 6.2 million have died due to SARS-CoV-2. There are treatments but no cures for most viruses. Nevertheless, the spread of viruses can be limited by introducing antiviral coatings on public area surfaces and personal protective equipment (e.g., face masks). This work aims to fabricate a polymer-based coating with acrylic resin as a binder that possesses great antiviral activity against the Feline coronavirus (FCov). The chosen polymer, polyethylene glycol (PEG), is used as an antiviral agent because it contains “green” chemistry benefits such as non-toxicity, being inexpensive, readily recyclable, safe, natural, non-flammable, biocompatible, and biodegradable. The PEG/acrylic coating systems of different weight percentages were coated on the glass substrates by the spray-coating method and cured at room temperature for 24 hours. The developed PEG/acrylic coating system that contains 20 wt% of PEG exhibits the highest anti-viral activities (99.9% against FCov) compared to the other weight percentages. From this study, it has been observed that the hydrophilicity of the coating plays an important role in its antiviral activity. The developed coating has a hydrophilic property, in which the contact angle was measured at 83.28 ± 0.5°. The FTIR reveals that there are no existing toxic components or new components contained in the coating samples.
This paper aims to analyze the narratives that have emerged in the process of bureaucratic reform in Indonesia. The analysis is conducted using the Narrative Policy Framework at the mesa level. Using data from articles published in 6 credible national media about “bureaucratic reform” from 2010 to 2023. The collected data was classified according to the Narrative Policy Framework (NPF) elements in the article: Issue setting, the cause of the issue, plot, character (villain, victim, hero), and recommendations for solutions offered. There were 31 articles analyzed. The result showed that the main plot in the process of bureaucratic reform in Indonesia is based on the corrupt bureaucracy and the slow public service provided. The victims in the plot are the people who will access the services. The villains of the narrative are civil servants who do not improve the required competencies. The heroes of the narrative are several government institutions (Ministry of State Apparatus Utilization and Bureaucratic Reform, Commission of Corruption Eradication, and The Audit Board of The Republic of Indonesia) that are considered to expose the problem.
Recently, Agile project management has received significant academic and industry attention from due to its advantages, such as decreased costs and time, increased effectiveness, and adaptiveness towards challenging business environments. This study primarily aims to investigate the relationship between the success factors and Agile project management methodology adoption and examine the moderating effect of perceived compatibility. The technology-organization-environment (TOE) framework and technology acceptance theories (UTAUT, IDT, and TAM) were applied as the theoretical foundation of the current study. A survey questionnaire method was employed to achieve the study objectives, while quantitative primary data were gathered using a carefully designed methodological approach focusing on Omani oil and gas industry. The PLS-SEM technique and SmartPLS software were used for hypotheses testing and data analysis. Resultantly, readiness, technology utilization, organizational factors, and perceived compatibility were the significant factors that promoted Agile methodology adoption in the oil and gas industry. Perceived compatibility moderated the relationship between success factors and Agile methodology. The findings suggested that people, technology, and organizational factors facilitate the Agile methodology under the technology acceptance theories and frameworks. Relevant stakeholders should adopt the study outcomes to improve Agile methodology adoption.
This research explores the implementation of streamlined licensing frameworks and consolidated procedures for promoting renewable energy generation worldwide. An in-depth analysis of the challenges faced by renewable energy developers and the corresponding solutions was identified through a series of industry interviews. The study aims to shed light on the key barriers encountered during project development and implementation, as well as the strategies employed to overcome these obstacles. By conducting interviews with professionals from the renewable energy sector, the research uncovers a range of common challenges, including complex permitting processes, regulatory uncertainties, grid integration issues, and financial barriers. These challenges often lead to project delays, increased costs, and limited investment opportunities, thereby hindering the growth of renewable energy generation. However, the interviews also reveal various solutions and best practices employed by industry stakeholders to address these challenges effectively. These solutions encompass the implementation of streamlined licensing procedures, such as single licenses and one-stop services, to simplify and expedite the permitting process. Additionally, the development of clear and stable regulatory frameworks, collaboration between public and private entities, and improved grid infrastructure were identified as key strategies to overcome regulatory and grid integration challenges. The research findings highlight the importance of collaborative efforts between policymakers, industry players, and other relevant stakeholders to create an enabling environment for renewable energy development. By incorporating the identified solutions and best practices, policymakers can streamline regulatory processes, foster public-private partnerships, and enhance grid infrastructure, thus catalyzing the growth of renewable energy projects.
How to improve enterprise performance has been a research topic widely studied by scholars for a long time. As economic globalization deepens, the business competition becomes increasingly harsh. Technology-based small and medium-sized enterprises (SMEs) play an important role in the rapid development of the country’s economy, especially in China. This study aims to investigate the mediating effect of knowledge integration capability in the relationship between corporate social capital and enterprise performance. The sample group used in this study were 300 technology-based SMEs in China. The research tool was a questionnaire adapted from previous scholars, which passed assessment in terms of content validity and reliability. Data were analyzed using structural equation modelling. The results show that: 1) corporate social capital has a positive impact on enterprise performance, but the impact differs between well-performing and poor-performing enterprises; and 2) knowledge integration ability plays a mediating role in the relationship between corporate social capital and enterprise performance, and the mediating role is the same for both well-performing and poor-performing enterprises. But it played a partial mediating role in the good-performance comparison group and a complete mediating role in the poor-performance comparison group. This study is useful for enterprise management in cultivating and developing the abundant social capital of enterprises and expanding channels for knowledge integration ability to increase enterprise performance.
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