Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

In the fast-paced modern society, enhancing employees’ professional qualities through training has become crucial for enterprise development. However, training satisfaction remains under-studied, particularly in specialized sectors such as the coal industry. Purpose: This study aims to investigate the impact of personal characteristics, organizational characteristics, and training design on training satisfaction, utilizing Baldwin and Ford’s transfer of training model as the theoretical framework. The study identifies how these factors influence training satisfaction and provides actionable insights for improving training effectiveness in China’s coal industry. Design/Methodology/Approach: A cross-sectional design that allowed the study to capture data at one point in time from a large sample of employees was employed to conduct an online survey involving 251 employees from the Huaibei Mining Group in Anhui Province, China. The survey was administered over three months, capturing a diverse sample with nearly equal gender distribution (51% male, 49% female) and a majority aged between 21 and 40. The participants represented various educational backgrounds, with 52.19% holding an undergraduate degree and most occupying entry-level positions (74.9%), providing a broad workforce representation. Findings: The research indicated that personal traits were the chief predictor of training satisfaction, showing a beta coefficient of 0.585 (95% CI: [0.423, 0.747]). Linear regression modeling indicates that training satisfaction is strongly related to organizational attributes (β = 0.276 with a confidence interval of 95% [0.109, 0.443]). In contrast, training design did not appear to be a strong predictor (β = 0.094, 95% CI: [−0.012, 0.200]). Employee training satisfaction was the principal outcome measure, measured with a 5-point Likert scale. The independent variables covered personal characteristics, organizational characteristics, and training design, all measured through validated items taken from former research. The consistency of the questionnaire from the inside was strong, as Cronbach’s alpha values stood between 0.891 and 0.936. We completed statistical testing using SPSS 27.0, complemented by multiple linear regression, to study the interactions between the variables. Practical implications: This research contributes to the literature by emphasizing the necessity for context-specific training approaches within the coal industry. It highlights the importance of considering personal and organizational characteristics when designing training programs to enhance employee satisfaction. The study suggests further exploration of the multifaceted factors influencing training satisfaction, reinforcing the relevance of Baldwin and Ford’s theoretical model in understanding training effectiveness. Ultimately, the findings provide valuable insights for organizations seeking to improve training outcomes and foster a more engaged workforce. Conclusion: The study concluded that personal and organizational characteristics significantly impact employee training satisfaction in the coal industry, with personal characteristics being the strongest predictor. The beta coefficient for personal characteristics was 0.585, indicating a strong positive relationship. Organizational characteristics also had a positive effect, with a beta coefficient of 0.276. However, training design did not show a significant impact on training satisfaction. These findings highlight the need for coal companies to focus on personal and organizational factors when designing training programs to enhance satisfaction and improve training outcomes.

Increasing number of smart cities, the rise of technology and urban population engagement in urban management, and the scarcity of open data for evaluating sustainable urban development determines the necessity of developing new sustainability assessment approaches. This study uses passive crowdsourcing together with the adapted SULPiTER (Sustainable Urban Logistics Planning to Enhance Regional freight transport) methodology to assess the sustainable development of smart cities. The proposed methodology considers economic, environmental, social, transport, communication factors and residents’ satisfaction with the urban environment. The SULPiTER relies on experts in selection of relevant factors and determining their contribution to the value of a sustainability indicator. We propose an alternative approach based on automated data gathering and processing. To implement it, we build an information service around a formal knowledge base that accumulates alternative workflows for estimation of indicators and allows for automatic comparison of alternatives and aggregation of their results. A system architecture was proposed and implemented with the Astana Opinion Mining service as its part that can be adjusted to collect opinions in various impact areas. The findings hold value for early identification of problems, and increasing planning and policies efficiency in sustainable urban development.

The regulation of compressor extraction and energy storage can improve the performance of gas turbine energy system. In order to make the gas turbine system match the external load more flexibly and efficiently, a gas turbine cogeneration system with solar energy coupling compressor outlet extraction and energy storage is proposed. By establishing the variable condition mathematical model of air turbine, waste heat boiler and solar collector, we use Thermoflex software to establish the variable condition model of gas turbine compressor outlet extraction, and analyze the variable condition of the coupling system to study the changes of thermal parameters of the system in the energy storage, energy release and operation cycle. Taking the hourly load of a hotel in South China as an example, this paper analyzes the case of the cogeneration system of solar energy coupling compressor outlet extraction and energy storage, and compares it with the benchmark cogeneration system. The results show that taking a typical day as a cycle, the primary energy utilization rate of the system designed in this paper is 3.2% higher than that of the traditional cogeneration system, and the efficiency is 2.4% higher.

In the teaching of graphic design, students' learning state and learning effect are poor due to the lack of attractiveness of teaching materials. In order to fully display the graphic design knowledge contained in totem patterns, a model based on the pattern elements of totem patterns was constructed. Through Marvelous Designer software, the display of totem visual effects under different pattern element configurations was realized, providing a basis for the comparative explanation of graphic design teaching. When designing the teaching content, based on the totem art culture, it has constructed three parts of teaching methods of plane composition, teaching contents of plane composition and teaching concepts of plane composition, which correspond to the material selection, composition and freehand brushwork skills of totem patterns in modeling creativity and expression techniques, and the range of material selection, composition form and connotation of plane design teaching, the specific application is realized through knowledge transfer.

Relational database models offer a pathway for the storage, standardization, and analysis of factors influencing national sports development. While existing research delves into the factors linked with sporting success, there remains an unexplored avenue for the design of databases that seamlessly integrate quantitative analyses of these factors. This study aims to design a relational database to store and analyse quantitative sport development data by employing information technology tools. The database design was carried out in three phases: (i) exploratory study for context analysis, identification, and delimitation of the data scope; (ii) data extraction from primary sources and cataloguing; (iii) database design to allow an integrated analysis of different dimensions and production of quantitative indicators. An entity-relationship diagram and an entity-relationship model were built to organize and store information relating to sports, organizations, people, investments, venues, facilities, materials, events, and sports results, enabling the sharing of data across tables and avoiding redundancies. This strategy demonstrated potential for future knowledge advancement by including the establishment of perpetual data updates through coding and web scraping. This, in turn, empowers the continuous evaluation and vigilance of organizational performance metrics and sports development policies, aligning seamlessly with the journal’s focus on cutting-edge methodologies in the realm of digital technology.