Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

Organomineral fertilizer is used to improve and ameliorate the supply of nutrients in soils. Right and adequate application of fertilizers are determinants of its nutrient supply efficiency, which in turn enhances the vegetative growth and yield of cucumber. Field experiments were conducted at the Research Farm of the Federal University of Agriculture, Abeokuta, Nigeria, to assess the effects of variety and rate of organomineral fertilizer on cucumber growth and yield. Trials were conducted from June to August 2019 and repeated from September to November 2019. The cultivars were Poinsett, Greengo, and Monalisa. The rates of organomineral fertilizer were 0, 2.5, or 5.0 tons. ha⁻¹. The treatments were replicated three times. Cucumber vegetative characters, yield, and yield components were studied. ‘Greengo’ produced the most leaves, followed by ‘Monalisa’; ‘Poinsett’ produced the least. Application of 5.0 tons. ha⁻¹ organomineral fertilizer produced the longest vines and fruits. ‘Greengo’ had the earliest days to 50% flowering, followed by ‘Monalisa’; ‘Poinsett’ had the most days to 50% flowering. Plants treated with an application of 5.0 tons. ha⁻¹ organomineral fertilizer attained 50% flowering in 29 days, but in 30 days with an application of 2.5 tons. ha⁻¹ organomineral fertilizer; the control treatment attained 50% flowering in 33 days. Application of 5.0 tons. ha⁻¹ organomineral fertilizer produced the longest fruits, thicker fruit diameter, and highest fruit yield compared with 2.5 and 0 tons. ha⁻¹ of organomineral fertilizer treatments. The Greengo variety with application of 5.0 tons. ha⁻¹ of organomineral fertilizer is recommended for optimum growth and yield in south western Nigeria.

Purpose: This study investigates the mediating effect of Environmental Attachment (EA) among consumers in an emerging market, concentrating on the impact of two key factors: Green Environmental Awareness (GEA) and Sense of Responsibility (SOR) on Sustainable Product Consumption (SPC). Design/methodology/approach: A thorough online survey was carried out with Google Docs and distributed to 304 Pakistani consumers who now use or are considering purchasing sustainable or green products. Structural Equation Modeling (SEM) was used to rigorously test the suggested model utilizing a non-probability sampling technique, specifically the stratified purposive sampling approach. Findings: Green environmental awareness (GEA) and a sense of responsibility (SOR) have been shown to have a substantial impact on creating environmental attachment (EA) in both existing and potential customers of sustainable products. The findings of this study also revealed that environmental attachment (EA) plays an important role as a mediator in the links between green environmental awareness (GEA) and the consumption of sustainable goods (SPC), as well as between a sense of responsibility (SOR) and SPC. Despite this, it is crucial to note that the projected direct effect of GEA on SPC was shown to be statistically insignificant. This conclusion implies that additional factors outside the scope of this study may influence the relationship between GEA and SPC. Research limitations/implications: It is vital to highlight that the focus of this study is on an online sample of consumers near Punjab, Pakistan. Future studies should look at other parts of Pakistan to acquire a more complete picture of sustainable consumption trends. Furthermore, our findings suggest that characteristics impacting sustainable consumption, such as Green Environmental Awareness (GEA) and Sense of Responsibility (SOR), may differ among countries. As a result, performing a comparison analysis involving two or more countries could provide valuable insights into projecting sustainable product consumption among current and potential sustainable product customers. Originality/Value: This study contributes to the literature by investigating the factors of sustainable consumption using the lens of the Norm Activation Model theory (NAM), notably Green Environmental Awareness (GEA) and Sense of Responsibility (SOR), to predict sustainable product consumption. The findings are important for promoting long-term goals in Pakistan and provide a framework that can be applied in other emerging markets.

Background: According to the 2023 World Economic Forum report, the impact of Artificial Intelligence (AI) and automation on the job market was more significant than originally projected. Although 2018 research forecasted significant job losses balanced by job creation, current data indicates otherwise. Between 2023 and 2027, it is anticipated that 69 million new jobs will be created due to advancements in AI, however, this will be offset by the loss of 83 million jobs, leading to a net decrease of 14 million jobs worldwide. Roles related to AI, digitalization, and sustainability, such as AI specialists and renewable energy engineers are expected to grow, while those in clerical and administrative sectors are most at risk of decline. This shift underscores the need for reskilling and adapting to evolving fields, as nearly 44% of workers skills will face disruption by 2027. The demand for analytical thinking, technological literacy, and adaptability will grow as companies increasingly adopt frontier technologies. Objectives: (1) identify key variables influencing adaptability of college graduates in Indonesia, (2) quantify the strength of relationships between these variables to understand the combined effect on graduate adaptability. The research also aims to (3) develop theoretical and practical recommendations to strengthen ICIL policy and equip students with the relevant skills needed to thrive in an ever-changing job market. Methodology: The research focuses on predicting future employment trends, adaptability, and learning agility (LA), along with the implications for improving the Independent Campus Independent Learning (ICIL) policy. It focused on the significant unemployment rate among college graduates, along with the lack of research on the relationship between job change predictions, graduates’ adaptability, and the impact on graduates’ general well-being. The mixed-method strategy with quantitative analysis was used to conduct this research with data collected from 284 ICIL participants through online survey. The gathered data was evaluated using Structural Equation Modeling (SEM) with Lisrel version 10. Results: The result showed that job trend projections significantly influence responsiveness, which demonstrated a robust association between employment trend predictions and LA. Responsiveness significantly influenced learning agility which indicated no significant direct association between job trend projections and graduate adaptability. Conclusion: The research emphasized the need to consider adaptability as a concept with multiple dimensions. It proposed incorporating these factors into strategies for education and human resources development in order to better equip graduates for the demands of a constantly changing work market. Unique contribution: This research focused on adaptability as a multifaceted concept that consist of the ability to forecast job trends, be sensitive, and possess LA. It offered a deeper understanding of the relationships between these variables as discussed in the human resources literature. Technology, corporate culture, and training played a critical role in connecting employment trend prediction with the ability to respond effectively. Key recommendation: Institutions should implement a comprehensive approach to the development of human resources, with emphasis on fostering critical thinking, analytical abilities, and the practical application of information. By employing these tactics, higher education institutions may effectively equip graduates with both academic proficiency and the ability to adapt and thrive in quickly changing organizational environments, leading to the production of robust and versatile workers.

The 2019 Social Enterprise Promotion Act in Thailand represents a pivotal step towards promoting social enterprises by fostering self-reliance and a fair and sustainable future for the country. Despite their significance, there is a noticeable research gap focusing on the factors that motivate Thai entrepreneurs to venture into social entrepreneurship. This study seeks to fill that gap by analyzing data from 2000 respondents in Thailand, utilizing linear regression to explore whether the awareness of the United Nations Sustainable Development Goals (SDGs), the adoption of digital technologies, extrinsic motivations, such as the overall societal view of entrepreneurs, social awareness, and perceptions of entrepreneurial capabilities influence the decision to start a social enterprise. In a gender comparison, our findings reveal that the societal context plays a crucial role for both genders, although in distinct ways: Male entrepreneurs are more influenced by individualistic extrinsic values, with motivations linked to power, respect, and societal recognition. In contrast, female entrepreneurs display a collectivistic orientation, being more likely to be inspired by intrinsic motivations, such as the success and visibility of other successful startups within their society. These findings underline the need for a gender-sensitive approach by government bodies, educational institutions, and other relevant organizations aiming to boost start-up rates of enterprises who “make a difference in the world”. Tailored support and educational programs to address the unique motivations and perspectives of male and female entrepreneurs could play a crucial role in enhancing the effectiveness of strategies designed to promote social entrepreneurship in Thailand and beyond.