According to the World Health Organization (WHO), breast cancer is among the most common cancers worldwide. Most of the anticancer agents have been showing a variety of side effects. Recently, bacterial proteins have been investigated as promising anticancer agents. Azurin is a bacterial cupredoxin protein secreted from Pseudomonas aeruginosa and has been reported as a potent multi-targeting anticancer agent, which makes it an appropriate candidate for drug delivery. Azurin may be delivered to cancer cells using different carriers like polymeric micro and nanoparticles. In the present study, azurin was extracted from the bacterial host and loaded into chitosan particles. Then its effect on MCF-7 cell line was investigated. Chitosan-azurin particles were made using the ion gelation method. Results showed that chitosan-azurin particles are about 200 nm, and the loading of the protein in particles did not affect its integrity. The MTT assay showed a significant reduction in cell viability in azurin and chitosan-azurin-treated cells. The toxicity level after 5 days was 63.78% and 82.53% for free azurin and chitosan-azurin-treated cells, respectively. It seems using an appropriate carrier system for anticancer proteins like azurin is a promising tool for developing low side effect anticancer agents.

Species of the Moraceae family are of great economic, medicinal and ecological importance in Amazonia. However, there are few studies on their diversity and population dynamics in residual forests. The objective was to determine the composition, structure and ecological importance of Moraceae in a residual forest. The applied method was descriptive and consisted of establishing 16 plots of 20 m × 50 m (0.10 ha), in a residual forest of the Alexánder von Humboldt substation of the National Institute of Agrarian Innovation-INIA, Pucallpa, department of Ucayali, where individuals of arboreal or hemi-epiphytic habit, with DBH ≥ 2.50 cm, were evaluated. The floristic composition was represented by 33 species, distributed in 12 genera; five species not recorded for Ucayali were found. Structurally, the family was represented by 138 individuals/ha with a horizontal distribution similar to an irregular inverted “J”. However, there were different horizontal structures among species. It was determined that 85% of the species were in diameter class I (2.50 to 9.99 cm), being the most abundant Pseudolmedia laevis (Ruiz & Pav.) J.F. Macbr. (41.88 individuals/ha); and the most dominant were Brosimum utile (Kunth) Oken (1.71 m²∕ha) and Brosimum alicastrum subsp. bolivarense (Pittier) C.C.Berg (0.90 m²/ha). Likewise, P. laevis and B. utile were the most ecologically important. The information from the present research will allow the establishment of a baseline, which can be used to propose the management of Moraceae in residual forests in the same study area.

Control of key technological and benchmark flows of polymer fluids poses a number of challenges. Some of them are nowadays under active investigation and rather far from complete under­stan­ding. This review considers such phenomena as both practically important and governed by funda­mental laws of rheology and non-linear fluid mechanics. We observe, shear bands in polymeric and other complex structured fluids (like wormlike micellar solutions or soft glassy materials), birefrigerent strands, peculiarities of stress and pressure losses in fluids moving through com­plex shape domains. These and other processes involve in­ho­mo­geneity, in­stabilities and tran­sient modes creeping in flow fields. In practical aspect this is of interest in such industrial process as polymer flooding for Enhanced Oil Recovery (EOR), where a flow inhomogeneity affects a poly­mer solution injectivity and residual oil saturation. The value of viscoelasticity in the polymer flooding is estimated. The obser­va­tion is con­clu­ded by some new results on relation between polymer concentration in solutions and viscoelastic traits of benchmark flows.

The Belt and Road Initiative (BRI) aims to enhance connectivity and collaboration among 60 countries and beyond in Asia, Africa and Europe. Information and communications technology (ICT) is an indispensable component of the initiative, critical in providing fundamental communication channels for global financial transactions, trade exchanges and transport and energy connectivity, and socio cultural collaboration and scientific exchanges between people, organizations and countries along the BRI corridors. Previously constrained by infrastructure deficits in ICT, the Asia-Pacific region is accelerating its efforts to provide reliable and affordable broadband networks throughout the region, to contribute to successful implementation of the Sustainable Development Goals (SDG).

Within the BRI corridors, this study which has been undertaken as part of the research programme of the United Nations Economic and Social Commission for Asia and the Pacific (ESCAP) on promoting regional economic cooperation and integration, focuses on the China-Central Asia Corridor (China, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan), giving attention to the sub-region’s specific challenges, namely limited international transit opportunities and an increase in bandwidth requirements that is expected to grow exponentially, as the fourth industrial evolution centered on automation and artificial intelligence gathers momentum. The sub-region is characterized as highly dependent on the ease and costs of connecting to neighboring countries for transit, as many countries in the sub-region are landlocked developing countries (LLDC). Because of the geographical features and other factors, the development potential of Central Asia and its integration into globalization, continues to be stymied by insufficient international bandwidth and high transit costs to access international links. Therefore, improved ICT connectivity in Central Asia through the BRI corridor could result in improved availability and affordability of broadband networks and services in the sub-region.

For the purpose of this study, a gap analysis is the methodology that underpins the proposed topology for the China-Central Asia Corridor. The analysis included examining the current state of the optic infrastructure, such as existing and planned fiber-optic networks, existing Internet Exchange Points (IXPs) and international gateways. The study also identifies the key factors that determine the desired future state of infrastructure deployment for the BRI initiative. A topology that consists of connecting Almaty (Kazakhstan) and Urumqi (China), as core nodes, is proposed based on a partial mesh topology. Over and above this core finding, the study concludes that digital infrastructure connectivity has a tendency of lagging behind the rapid opportunities evolving, and the study therefore advocates for sub-regional and regional approaches, including the BRI and Asia-Pacific Information Superhighway (AP-IS) in further expanding regional broadband networks. A key recommendation of the study is co-deployment of broadband infrastructure along passive infrastructure, as an additional cost effective means of achieving fast and affordable broadband connectivity for all.

The purpose of this paper is to introduce a new dimension of organizational collective engagement (OCE), namely spiritual engagement. This dimension proposes spiritual engagement, which is considered to increase the bundle of engagement as a whole at the organizational level. We collected data from 107 employees who worked in various agencies in Indonesia. We tested the validity and reliability of the proposed indicators of OCE and spiritual engagement using exploratory and confirmatory factor analysis. This study enhances the literature in the field of human resource development, especially in OCE, with the Islamic dimension of spiritual engagement. The findings reveal that there are 10 valid and reliable indicators that can be used to measure the concept of OCE among employees in Indonesia. OCE with four dimensions (physical, emotional, cognitive, and spiritual) can be an effort to increase organizational effectiveness through the collective engagement of all employees. Since this research is limited to Indonesia, further studies are needed in institutions around the world so that the consistency of the results can be justified.