Atomic interaction between mediator protein of human prostate cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use molecular dynamics (MD) approach based on Newton’s formalism to describe the destruction of PHPC via Fe/C720 Buckyballs-Statin with atomic accuracy. In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by universal force field (UFF) and DREIDING force-field to introduce their time evolution. The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27 Å to 2.96 Å after 10 ns. Physically, these interactions causing the destruction of the PHPC. Numerically, the volume of this biostructure enlarged from 665,276 Å3 to 737,143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry. Simulations indicated the volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.
Technology development in the agricultural sector is important in the development of Thailand’s economy. The purpose of this research was to study the approach of guidelines for future agricultural technology development to increase productivity in the Agricultural sector in order to develop a structural equation model. The research applied mixed-methodology. Qualitative research by in depth interview from 9 experts and focus group with 11 successful businesspersons for approve this model. The quantitative data gather from firm, in the 500 of agricultural sector by using questionnaire, using statistical tests of descriptive analysis, inferential analysis, and multivariate analysis. The research found guidelines for future agricultural technology development to increase productivity in the Agricultural sector composed of 4 latent. The most important item of each latent were as following: 1) Agrobiology Technology (= 4.41), in important item as choose seeds that for disease resistance and tolerate the environment to suit the cultivation area, 2) Environmental Assessment (= 4.37),, in important item as survey of cultivated areas according to topography with geographic information system, 3) Agricultural Innovation (= 4.30), in important item as technology reduces operational procedures, reduce the workforce and can reduce operating costs, and 4) Modern Management Systems (= 4.13), in important item as grouping and manage as a cooperative to mega farms. In addition, the hypothesis test found that the difference in manufacturing firm sizes. Medium and Small size and large size revealed overall aspects that were significantly different at the level of 0.05. The analysis of the developed structural equation model found that there was in accordance and fit with the empirical data and passed the evaluation criteria. Its Chi-square probability level, relative Chi-square, the goodness of fit index, and root mean square error of approximation were 0.062, 1.165, 0.961, and 0.018, respectively.
The rapid development of cities and urbanization in China has forced the growth of new channels for buying agricultural products. The purpose of this research is to examine how Internet of Things (IoT’s) technologies can digitize a traditional fresh food supply chain. Comparative and descriptive analysis methods are used to highlight the major pain points in the traditional supply chains and assess how digital transformation could help. We delve into every part of digital transformation, which includes establishing an information platform based on IoT and developing smart storage options. Our findings revealed that through end-to-end digital integration, supply chain efficiency is improved with shorter lead times and leaner inventories that yield reduced costs as well as fewer losses while ensuring product quality and traceability. In sum, such an approach would enhance sustainability within the fresh food value chain. As such, our article highlights key aspects of transitioning towards a digital environment in this sector for those planning similar ventures.
The MENA region, known for its significant oil and gas production, has been widely acknowledged for its reliance on fossil fuels. The dependence on fossil fuels has led to significant environmental pollution. Therefore, the shift towards a more environmentally friendly and enduring future is crucial. Thus, the current study tries to investigate the effect of green technology innovations on green growth in MENA region. Specifically, we examine whether the effect of green technology innovations on green growth depend on the threshold level of income. To this end, a panel threshold model is estimated for a sample of 10 MENA countries over the period 1998–2022. Our main findings show that only countries with income level beyond the threshold can benefit significantly from green technology innovations in term of green growth. Nevertheless, our findings indicate a substantial and adverse impact of green technology innovation on countries where income levels fall below the specified threshold.
The global economic recession has caused pessimism in terms of prospects of sales recovering in the future. The present study is an attempt to investigate the cost stickiness behavior by focusing on specific characteristics of companies. The research was done through documentary analysis and access to quantitative data, with the use of statistical methods for analysis as panel data. The statistical population of the actual study included all companies listed on the India stock exchange from 2017 to 2021. They were selected after screening 128 listed companies. The regression method was used to examine the relationship between variables and to present a forecast model. The results of testing the first hypothesis showed that companies’ costs are sticky and according to the results of this hypothesis, an increase in costs when the level of activity increases is greater than the level of reduction in costs when the volumes of the activities are decreased. The results of the second hypothesis showed a remarkable relationship between the cost stickiness and specific characteristics of companies (size, number of employees, long-term assets, financial leverage, and accuracy of profits forecast). Based on the third hypothesis, there is a notable difference between cost stickiness at different levels of specific characteristics of companies. Therefore, the results show that environmental uncertainty such as COVID-19, increases cost stickiness.
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