The culture-loaded words are a special vocabulary of all kinds of language. And its translation has been one of the most difficult problems in the academic field. When culture-loaded words are being translated from the source language into the target language, the trans_x005flator should have a clear knowledge of the differences in understanding the same culture-loaded word of both the source language reader and the target language reader. This paper deals with strategies for optimizing the translation of culture-loaded words, especially translating Chinese culture-loaded words into English. Alienation translation favors communicating the characteristics and connotation of Chinese and English culture.