This study focused on the topic of competences and challenges faced by university teachers in Ecuadorian higher education. The objective of this study was to identify the essential competences that university teachers must possess to confront the current challenges in the Ecuadorian educational field. A mixed research methodology was utilized. A concurrent triangulation design (DITRIAC) was applied. The data collection technique was through documentary study and focus groups. Eight experts in Ecuadorian higher education participated as key informants. Among the findings, there was a consensus on 7 key competences (disciplinary mastery, pedagogical competences, technological skills, research and continuous updating, critical thinking development, ethical and social commitment, flexibility and adaptability to change). It was concluded that Ecuadorian higher education requires teaching professionals who not only master their disciplines and possess advanced pedagogical and technological skills, but who are also leaders in research, promoters of critical thinking, and exemplify ethical commitment and adaptability.