In the last several decades, cardiovascular diseases (CVDs) have emerged as a major hazard to human life and health. Conventional formulations for the treatment of CVD are available, but they are far from ideal because of poor water solubility, limited biological activity, non-targeting, and drug resistance. With the advancement of nanotechnology, a novel drug delivery approach for the treatment of CVDs has emerged: nano-drug delivery systems (NDDSs). NDDSs have shown significant advantages in tackling the difficulties listed above. Cytotoxicity is a difficulty with the use of non-destructive DNA sequences. NDDS categories and targeted tactics were outlined, as well as current research advancements in the diagnosis and treatment of CVDs. It’s possible that gene therapy might be included into nano-carriers in the delivery of cardiovascular medications in the future. In addition, the evaluation addressed the drug’s safety.

Tomato powdery mildew, fruit rot, and twig blight are all managed with Deltamethrin. Its residues could still be present in the crops, posing a health risk. The pesticide residue analysis, dissipation rate, and safety assessments were thus examined in green tomatoes. The analytical method for residue analysis was validated according to international standards. Tomato fruits and soil were used to study the dissipation of Deltamethrin 100 EC (11% w/w) at 12.5 g a.i ha⁻¹ for the recommended dose (RD) and 25.0 g a.i ha⁻¹ for the double of the recommended dose (DD). Ethyl acetate was used to extract residues from tomato fruit, and PSA and magnesium sulphate were used for cleanup.The fruits had recoveries ranging from 83% to 93% and the soil sample from 81.67% to 89.6%, with the limit of detection (LOQ) estimated at 0.01 mg kg⁻¹. The matrix effect (ME) was calculated to be less than 20% for the tomato fruits and the soil.Half-lives for RD and DD were 1.95 and 1.84 days, respectively. All sampling days for both doses had dietary exposures of residues below the maximum permissible intake (MPI) of 0.16 mg person⁻¹ day⁻¹. The most effective method of decontaminating tomato residue containing Deltamethrin is blanching.

The rapid growth of e-commerce in South Africa has increased the demand for efficient last-mile delivery. Motorcycle delivery drivers play a crucial role in the last-mile delivery process to bridge the gap between retailers and consumers. However, these drivers face significant challenges that impact both logistical efficiency and their socio-economic well-being. This study critically analyzes media narratives on the safety and working conditions of motorcycle delivery drivers in the e-commerce sector in South Africa. The thematic analysis of newspaper articles identified recurring themes. This study reveals critical safety and labor vulnerabilities affecting motorcycle delivery drivers in South Africa’s e-commerce sector. Key findings include heightened risks of violence, hijackings, and road accidents, exacerbated by inadequate infrastructure and safety gear. Coupled with low wages, job insecurity, and limited benefits, these conditions expose drivers to significant precarity. Policy interventions are urgently needed for driver safety and sustainable logistics. By integrating insights from multiple disciplines, this study offers a comprehensive understanding of the complex challenges within this rapidly growing sector.

Purpose: The study examines the mediating effect of self-emotion appraisal and other-emotion appraisal on psychological safety, individual resilience, and organizational commitment at the workplace. Design/methodology/approach: This study generated 140 survey responses from workers in diverse occupations and industries during the COVID-19 pandemic. A mixed-methods data analysis was conducted. Hierarchical regression analysis was employed to test the hypotheses, and process macroanalysis was used to generate the mediation analysis. Qualitative data analysis through thematic coding was adopted to interpret the respondents’ written opinions and narratives. Findings: The results revealed that self-emotion appraisal strongly correlates to resilience, but evaluation of self-emotion has no effect on organizational commitment. Other-emotion appraisal and psychological safety are not significant predictors of resilience at the workplace. Rather, psychological safety is a significant predictor of organizational commitment. The qualitative analysis generated from the respondents’ narratives provides deeper insight into the quantitative results. Additional data that emerged from the qualitative interpretation revealed other factors that are related to emotional appraisal, psychological safety, resilience, and organizational commitment. Practical implications: The findings shed light on the need to understand an individual’s emotional appraisal when instilling workplace resilience. Further, promoting psychological safety, such as by involving employees in the change process, managing fairness perception, and eliciting trust, enhances organizational commitment in the workplace. Integrating open communication, management intervention, and coaching programmes should form part of the employee engagement and development functions to help build organizational resilience and commitment. Originality/value: This research is an original contribution conducted during the global health crisis that led to abrupt changes in the workers’ lives and the workplaces in Singapore. Research implications: This present study demonstrated constructive findings on emotion regulations and perceived psychological safety associated with resilience and commitment amid the disruptive changes in work practices at the workplace. Further, the outcome of the study shows the mediating effect of self-emotional appraisal on psychological safety and resilience. The result draws parallels with past literature that showed that individuals who appraised their emotions tended to recalibrate and recognize their subjective behaviour and take actions to modify it. Social implications: Emotion regulation connotes employees’ emotion coping strategies, and research showed that emotion reappraisal produces a positive effect on workplace relationship quality.