The fast-growing field of nanotheranostics is revolutionizing cancer treatment by allowing for precise diagnosis and targeted therapy at the cellular and molecular levels. These nanoscale platforms provide considerable benefits in oncology, including improved disease and therapy specificity, lower systemic toxicity, and real-time monitoring of therapeutic outcomes. However, nanoparticles' complicated interactions with biological systems, notably the immune system, present significant obstacles for clinical translation. While certain nanoparticles can elicit favorable anti-tumor immune responses, others cause immunotoxicity, including complement activation-related pseudoallergy (CARPA), cytokine storms, chronic inflammation, and organ damage. Traditional toxicity evaluation approaches are frequently time-consuming, expensive, and insufficient to capture these intricate nanoparticle-biological interactions. Artificial intelligence (AI) and machine learning (ML) have emerged as transformational solutions to these problems. This paper summarizes current achievements in nanotheranostics for cancer, delves into the causes of nanoparticle-induced immunotoxicity, and demonstrates how AI/ML may help anticipate and create safer nanoparticles. Integrating AI/ML with modern computational approaches allows for the detection of potentially dangerous nanoparticle qualities, guides the optimization of physicochemical features, and speeds up the development of immune-compatible nanotheranostics suited to individual patients. The combination of nanotechnology with AI/ML has the potential to completely realize the therapeutic promise of nanotheranostics while assuring patient safety in the age of precision medicine.

Open-source software (OSS) has emerged as a transformative tool whose implementation has the potential to modernise many libraries around the world in the digital age. OSS is a type of software which permits its users to inspect, share, modify, and enhance through its freely accessed source code. The accessibility and openness of the source code permits users to manipulate, change, and improve the way in which a piece of software, program, or application works. OSS solutions therefore provide cost-effective alternatives that enable libraries to enhance their technological infrastructure without being constrained by proprietary systems. Hence, many countries have initiated and formulated policies and legislative frameworks to support the implementation and use of OSS library solutions such as DSpace, Alfresco, and Greenstone. The purpose of the study reported on was to investigate the leveraging of OSS to modernise public libraries in South Africa. Content analysis was adopted as the research methodology for this qualitative study, which was based on a literature review integrating insights from the researchers’ experiences with the use of OSS in libraries The findings of the study reveal that the use of OSS has the potential to modernise public libraries, especially those located outside cities or urban areas. These libraries are often less well equipped with the necessary technology infrastructure to meet the demands of the digital age, such as online books and open access materials. The study culminated in an OSS framework that may be implemented to modernise public libraries. This framework may help public libraries to integrate OSS solutions and further allow users access to digital services.

Rising fuel prices can affect driver behavior and thus the number of accidents, which is a key road safety issue. The aim of this paper was to assess and quantify the relationship between fuel prices (FP) and the number of road accidents in Europe. Content analysis of statistics from the countries was used to collect data, which were examined using Ramsey resets and Poisson distributions and then processed using negative binomial regression (NB), cluster analysis and visualization using contour plots. The results show that in Germany and Poland there is a statistically significant low negative correlation between fuel price and the number of traffic accidents, while in the Czech Republic and Denmark the relationship is weaker and statistically insignificant. In Iceland, no significant correlation was found. The contribution of this paper is to provide important insights that can be used in the development of transport policies and regulations to improve road safety. The main limitations include the difficulty of data collection, as many countries do not publish detailed statistics, and the low number of accidents in Iceland, which makes it impossible to perform a robust analysis for this country and may cause generalization of the results.

In the era of digital disruption, the imperative development of broadband services is evident. The emergence of 5G technology represents the latest stride in commercial broadband, offering data speeds poised to drive significant societal advancement. The midst of responding to this transformative phenomenon. This pursuit unveils a landscape replete with opportunities and challenges, particularly regarding how 5G’s potential benefits can drive the government towards equitable distribution, ensuring accessibility for all. Simultaneously, there exists a legal hurdle to ensure this vision’s fruition. From a legal perspective, perceived as infrastructure for transformation, the law must seamlessly adapt to and promptly address technological progress. Utilizing normative juridical methods and analytical techniques via literature review, this research endeavors to outline the advantages of 5G and scrutinize Indonesia’s latest telecommunications regulations and policies, alongside corresponding investments. The study ultimately aims to provide a juridical analysis of 5G implementation within Indonesia’s legal framework.

The tunable conduction of coumarin-based composites has attracted considerable attention in a wide range of applications due to their unique chemical structures and fascinating properties. The incorporation of graphene oxide (GO) further enhances coumarin properties, including strong fluorescence, reversible photodimerization, and good thermal stability, expanding their potential use in advanced technological applications. This review describes the developmental evolution from GO, GO-polymer, and coumarin-based polymer to the coumarin-GO composite, concerning their synthesis, characterization, unique properties, and wide applications. We especially highlight the outstanding progress in the synthesis and structural characteristics along with their physical and chemical properties. Therefore, understanding their structure-property relations is very important to acquire scientific and technological information for developing the advanced materials with interesting performance in optoelectronic and energy applications as well as in the biomedical field. Given the expertise of influenced factors (e.g., dispersion quality, functionalization, and loading level) on the overall extent of enhancement, future research directions include optimizing coumarin-GO composites by varying the nanofiller types and coumarin compositions, which could significantly promote the development of next-generation polymer composites for specific applications.