Background: Multiple sclerosis is often a longitudinal disease continuum with an initial relapsing-remitting phase (RRMS) and later secondary progression (SPMS). Most currently approved therapies are not sufficiently effective in SPMS. Early detection of SPMS conversion is therefore critical for therapy selection. Important decision-making tools may include testing of partial cognitive performance and magnetic resonance imaging (MRI). Aim of the work: To demonstrate the importance of cognitive testing and MRI for the prediction and detection of SPMS conversion. Elaboration of strategies for follow-up and therapy management in practice, especially in outpatient care. Material and methods: Review based on an unsystematic literature search. Results: Standardized cognitive testing can be helpful for early SPMS diagnosis and facilitate progression assessment. Annual use of sensitive screening tests such as Symbol Digit Modalities Test (SDMT) and Brief Visual Memory Test-Revised (BVMT-R) or the Brief International Cognitive Assessment for MS (BICAMS) test battery is recommended. Persistent inflammatory activity on MRI in the first three years of disease and the presence of cortical lesions are predictive of SPMS conversion. Standardized MRI monitoring for features of progressive MS can support clinically and neurocognitively based suspicion of SPMS. Discussion: Interdisciplinary care of MS patients by clinically skilled neurologists, supported by neuropsychological testing and MRI, has a high value for SPMS prediction and diagnosis. The latter allows early conversion to appropriate therapies, as SPMS requires different interventions than RRMS. After drug switching, clinical, neuropsychological, and imaging vigilance allows stringent monitoring for neuroinflammatory and degenerative activity as well as treatment complications.

The ways of developing functional textiles based on nanomaterials were introduced, and the latest research achievements of nanomaterials in such aspects as flame retardancy, antibacterial, super-hydrophobic, self-cleaning, UV resistance, and anti-static textiles were reviewed. The main technical obstacles to the large-scale application of nanomaterials in functional textiles were pointed out, the possible solutions were discussed, and the development of functional textiles by nanomaterials has been prospected.

The electron/hole transport layer can promote charge transfer and improve device performance, which is used in perovskite solar cells. The nanoarray structure transport layers can not only further promote carrier transport but also reduce recombination. It also has a great potential in enhancing perovskite light absorption, improving device stability and inhibiting the crack nucleation of different structure layers in perovskite solar cells. This paper reviewed the research progress of perovskite solar cells with different nanoarray structure transport layers. The challenges and development directions of perovskite solar cells based on nanoarray structure transport layers are also summarized and prospected.

Cucumis sativus is an important vegetable crop in the world. Agrobacterium mediated transgenic technology is an important means to study plant gene function and variety improvement. In order to further accelerate the transgenic research and breeding process of cucumber, aiming at the Agrobacterium mediated genetic transformation method of cucumber, this paper expounds the research progress and existing problems of Agrobacterium mediated transgenic cucumber from the aspects of influencing factors of cucumber regeneration ability, genetic transformation conditions and various added substances in the process, and prospects the future of improving the efficiency of cucumber genetic transformation and the application of safety screening markers, in order to provide reference for cucumber stress resistance breeding and fruit quality improvement.

This paper concerns a miniature gasifier fed with a constant ambient-pressure flow of air to study the pyrolysis and subsequent combustion stage of a single wood pellet at T = 800 ℃. The alkali release and the concentration of simple gases were recorded simultaneously using an improved alkali surface ionisation detector and a mass spectrometer in time steps of 1 s and 1.2 s, respectively. It showed alkali release during both stages. During combustion, the MS data showed almost complete oxidation of the charred pellet to CO₂. The derived alkali release, “O₂ consumed”, and “CO₂ produced” conversion rates all indicated very similar temporal growth and coalescence features with respect to the varying char pore surface area underlying the original random pore model of Bhatia and Perlmutter. But, also large, rapid signal accelerations near the end and marked peak-tails with O₂ and CO₂ after that, but not with the alkali release data. The latter features appear indicative of alkali–deprived char attributable to the preceding pyrolysis with flowing air. Except for the peak-tails, all other features were reproduced well with the modified model equations of Struis et al. and the parameter values resembled closely those reported for fir charcoal gasified with CO₂ at T = 800 ℃.