The COVID-19 pandemic has instigated global lockdowns, profoundly altering daily life and resulting in widespread closures, except for essential services like healthcare and grocery stores. This scenario has notably intensified mental health challenges, particularly among children and adolescents. Influenced by a myriad of factors including developmental stages, educational backgrounds, existing psychiatric disorders, and socioeconomic status, the pandemic’s impact extends beyond the immediate health crisis. This paper critically examines the multifaceted effects of the pandemic on mental and physical health across various age groups. It highlights the increased incidence of stress, anxiety, and depression, underscoring the pandemic’s deep psychological footprint. Additionally, the paper explores the societal implications, from altered family dynamics and educational disruptions due to the shift to online learning, to workplace transformations. These changes have led to a mix of adaptive responses and adverse effects, including heightened domestic tensions and mental health issues. The paper also delves into the ethical challenges faced by medical professionals during this crisis, balancing urgent patient care with ongoing medical research and mental health considerations. This analysis aims to provide a comprehensive understanding of the COVID-19 pandemic’s extensive impact on health and society, emphasizing the importance of addressing mental health as a crucial component of the response strategy.

This study investigates the impact of human resource management (HRM) practices on employee retention and job satisfaction within Malaysia’s IT industry. The research centered on middle-management executives from the top 10 IT companies in the Greater Klang Valley and Penang. Using a self-administered questionnaire, the study gathered data on demographic characteristics, HRM practices, and employee retention, with the questionnaire design drawing from established literature and validated measuring scales. The study employed the PLS 4.0 method for analyzing structural relationships and tested various hypotheses regarding HRM practices and employee retention. Key findings revealed that work-life balance did not significantly impact employee retention. Conversely, job security positively influenced employee retention. Notably, rewards, recognition, and training and development were found to be insignificant in predicting employee retention. Additionally, the study explored the mediating role of job satisfaction but found it did not mediate the relationship between work-life balance and employee retention nor between job security and employee retention. The research highlighted that HRM practices have diverse effects on employee retention in Malaysia’s IT sector. Acknowledging limitations like sample size and research design, the study suggests the need for further research to deepen understanding in this area.

This study uses dynamic capability theory and a resource-based view to examine whether intellectual capital (human, relational, and structural capital) mediates entrepreneurial leadership and innovation success. Drawing on data from 422 senior-level employees working in Peruvian I.T. companies, the proposed relationships were analyzed using SmartPLS 4. Entrepreneurial leadership was found to foster employees’ innovative performance through the mediating role of human capital, relational capital, and structural capital. Practically, businesses often rely on innovation for survival and growth, so they should consider entrepreneurial leadership to create intellectual capital (human capital, relational capital and structural capital) for innovation performance. Businesses should provide entrepreneurial training that emphasizes role modeling intellectual capital and encourages employees to recognize and pursue entrepreneurial opportunities. With significantly limited research, the study contributes by investigating the interrelationship of entrepreneurial leadership, intellectual capital, and innovation performance. The study contributes to the Resource Based View and Dynamic Capability Theory by demonstrating how entrepreneurial leadership contributes to innovation performance through human capital, relational capital, and structural capital.

Instant and accurate evaluation of drug resistance in tumors before and during chemotherapy is important for patients with advanced colon cancer and is beneficial for prolonging their progression-free survival time. Here, the possible biomarkers that reflect the drug resistance of colon cancer were investigated using proton magnetic resonance spectroscopy (1H-MRS) in vivo. SW480[5-fluorouracil(5-FU)-responsive] and SW480/5-FU (5-FU-resistant) xenograft models were generated and subjected to in vivo 1H-MRS examinations when the maximum tumor diameter reached 1–1.5 cm. The areas under the peaks for metabolites, including choline (Cho), lactate (Lac), glutamine/glutamate (Glx), and myo-inositol (Ins)/creatine (Cr) in the tumors, were analyzed between two groups. The resistance-related protein expression, cell morphology, necrosis, apoptosis, and cell survival of these tumor specimens were assessed. The content for tCho, Lac, Glx, and Ins/Cr in the tumors of the SW480 group was significantly lower than that of the SW480/5-FU group (P < 0.05). While there was no significant difference in the degree of necrosis and apoptosis rate of tumor cells between the two groups (P > 0.05), the tumor cells of the SW480/5-FU showed a higher cell density and larger nuclei. The expression levels of resistance-related proteins (P-gp, MPR1, PKC) in the SW480 group were lower than those in the SW480/5-FU group (P < 0.01). The survival rate of 5-FU-resistant colon cancer cells was significantly higher than that of 5-FU-responsive ones at 5-FU concentrations greater than 2.5 μg/mL (P < 0.05). These results suggest that alterations in tCho, Lac, Glx1, Glx2, and Ins/Cr detected by 1H-MRS may be used for monitoring tumor resistance to 5-FU in vivo.

This research examines intangible assets or intellectual capital (IC) performance of tourism-related industries in an underexplored area which is a tourism intensively-dependent country. In this study, VAIC which is a monetary valuation method and also the most widely applied measurement method, is utilized as the performance measurement method for quantifying IC performance to monetary values. Moreover, to better understand performance, the standard efficiency levels are further applied for classifying the performance levels of tourism industries. The sample sizes of study are 20 companies operating in the tourism-related industries in the world top travel destination or Thailand, and the companies’ data are collected from 2012 to 2021. Therefore, finally, there are 187 firm-year observations. The utilization of VAIC could assess IC performance of tourism firms and industries, and the standard efficiency levels further support the uniform interpretation of IC efficiency levels. The obtained results show the strong performance of both human and structural capital of the focused tourism dependent country especially in the logistics industry that directly supports and connects to the tourism attractions. Moreover, the finding also highlights the significance of human capital which plays as a major contributor for overall IC performance in this tourism dependent economy. This study contributes the new exploration of IC in the high impact industries and also specifically in the top significant tourism country. Moreover, the application of VAIC also confirms a practical application for management. The limited number of studied countries is a limitation of study. However, these new obtained data and information could be further applied for making comparisons or in-depth or statistical analysis in the future works.

Manual scavenging refers to the practice of manually cleaning, carrying, disposing or handling human excreta from dry latrines and sewers. It is one of the most dehumanizing and deplorable practices that violate basic human rights and dignity. This practice is linked to India’s caste system where so-called lower castes are expected to perform this job. Despite being outlawed in 1993, manual scavenging continues to exist in India due to socio-economic discrimination and lack of rehabilitation of manual scavengers. This paper attempts to provide an in-depth understanding. The harsh realities by qualitative systemic review of manual scavenging in India and how it negatively impacts human rights. It reviews relevant literature on the prevalence, causes, adverse effects, and laws against manual scavenging. The results indicate that manual scavenging is still practiced across many states in India. Manual scavengers face grave health hazards and socio-economic hardships. The laws against manual scavenging have failed to abolish this practice due to administrative apathy, lack of rehabilitation support for liberated scavengers, and continued prevalence of dry latrines necessitating manual disposal of excreta. The paper emphasizes the need for more concerted efforts by the government and civil society to end manual scavenging to uphold human rights, dignity, and justice for all. There is an urgent need for extensive awareness campaigns, social support, and proper rehabilitation of liberated scavengers into alternative professions.