In recent years, the pathological diagnosis of glomerular diseases typically involves the study of glomerular his-to pathology by specialized pathologists, who analyze tissue sections stained with Periodic Acid-Schiff (PAS) to assess tissue and cellular abnormalities. In recent years, the rapid development of generative adversarial networks composed of generators and discriminators has led to further developments in image colorization tasks. In this paper, we present a generative adversarial network by Spectral Normalization colorization designed for color restoration of grayscale images depicting glomerular cell tissue elements. The network consists of two structures: the generator and the discriminator. The generator incorporates a U-shaped decoder and encoder network to extract feature information from input images, extract features from Lab color space images, and predict color distribution. The discriminator network is responsible for optimizing the generated colorized images by comparing them with real stained images. On the Human Biomolecular Atlas Program (HubMAP)—Hacking the Kidney FTU segmentation challenge dataset, we achieved a peak signal-to-noise ratio of 29.802 dB, along with high structural similarity results as other colorization methods. This colorization method offers an approach to add color to grayscale images of glomerular cell tissue units. It facilitates the observation of physiological information in pathological images by doctors and patients, enabling better pathological-assisted diagnosis of certain kidney diseases.

Stimuli-responsive, smart, or intelligent polymers are materials that significantly change their physical or chemical properties when there is a small change in the surrounding environment due to either internal or external stimuli. In the last two decades or so, there has been tremendous growth in the strategies to develop various types of stimuli-responsive polymer (SRP) materials/systems that are suitable for various fields, including biomedical, material science, nanotechnology, biotechnology, surface and colloid sciences, biochemistry, and the environmental field. The wide acceptability of SRPs is due to their availability in different architectural forms such as scaffolds, aggregates, hydrogels, pickering emulsions, core-shell particles, nanogels, micelles, membranes, capsules, and layer-by-layer films. The present review focuses on different types of SRPs, such as physical, chemical, and biological, and various important applications, including controlled drug delivery (CDD), stabilization of colloidal dispersion, diagnostics (sensors and imaging), tissue engineering, regenerative medicines, and actuators. The applications of SRPs have immense potential in various fields, and the author hopes these polymers will add a new field of applications through new concepts.

Recent technological advances in the fields of biomaterials and tissue engineering have spurred interest in biopolymers for various biomedical applications. The advantage of biopolymers is their favorable characteristics for these applications, among which proteins are of particular importance. Proteins are explored widely for 3D bioprinting and tissue engineering applications, wound healing, drug delivery systems, implants, etc., and the proteins mainly available include collagen, gelatin, albumin, zein, etc. Zein is a plant protein abundantly present in corn endosperm, and it is about 80% of total corn protein. It is a highly renewable source, and zein has been reported to be applicable in different industrial applications. Lately, it has gained attention in biomedical applications. This research interest in zein is on account of its biocompatibility, non-toxicity, and certain unique physico-chemical properties. Zein comes under the GRAS category and is considered safe for biomedical applications. The hydrophobic nature of this protein gives it an added advantage and has wider applications in drug delivery. This review focuses on details about zein protein, its properties, and potential applications in biomedical sectors.

Recently, carbon nanocomposites have garnered a lot of curiosity because of their distinctive characteristics and extensive variety of possible possibilities. Among all of these applications, the development of sensors with electrochemical properties based on carbon nanocomposites for use in biomedicine has shown as an area with potential. These sensors are suitable for an assortment of biomedical applications, such as prescribing medications, disease diagnostics, and biomarker detection. They have many benefits, including outstanding sensitivity, selectivity, and low limitations on detection. This comprehensive review aims to provide an in-depth analysis of the recent advancements in carbon nanocomposites-based electrochemical sensors for biomedical applications. The different types of carbon nanomaterials used in sensor fabrication, their synthesis methods, and the functionalization techniques employed to enhance their sensing properties have been discussed. Furthermore, we enumerate the numerous biological and biomedical uses of electrochemical sensors based on carbon nanocomposites, among them their employment in illness diagnosis, physiological parameter monitoring, and biomolecule detection. The challenges and prospects of these sensors in biomedical applications are also discussed. Overall, this review highlights the tremendous potential of carbon nanomaterial-based electrochemical sensors in revolutionizing biomedical research and clinical diagnostics.