The H3N2 influenza virus is spiking dramatically, which is a major concern worldwide and in India. The multifunctional hetero-trimer influenza virus RNA-dependent RNA polymerase (RdRP) is involved in the generation of viral mRNA and is crucial for viral infectivity, which is directly related to the virus’s ability to survive. The goal of the current work was to use molecular docking to determine how the RdRP protein might be affected by powerful bioactive chemicals found in Calotropis gigantia latex. By applying CB-dock 2 analysis and 2D interactions, an in-silico docking study was conducted using a GC-FID (gas chromatography with flame-ionization detection) based composition profile. Tocospiro A (15%), Amyrin (7%), and Gombasterol A were found by GC-FID to be the main phytocompounds in the latex of Calotropis gigantia. The docking result showed that ligands were effectively bound to RdRP. According to interaction studies, RdRP/ligand complexes create hydrogen bonds, van der Waals forces, pi-alkyl bonds, alkyl bonds, and pi-Sigma bonds. Therefore, it was suggested that Calotropis gigantia latex may represent a possible herbal remedy to attenuate H3N2 infections based on the above findings of the fragrance profile and docking.

The Belt and Road Initiative (BRI) aims to enhance connectivity and collaboration among 60 countries and beyond in Asia, Africa and Europe. Information and communications technology (ICT) is an indispensable component of the initiative, critical in providing fundamental communication channels for global financial transactions, trade exchanges and transport and energy connectivity, and socio cultural collaboration and scientific exchanges between people, organizations and countries along the BRI corridors. Previously constrained by infrastructure deficits in ICT, the Asia-Pacific region is accelerating its efforts to provide reliable and affordable broadband networks throughout the region, to contribute to successful implementation of the Sustainable Development Goals (SDG).

Within the BRI corridors, this study which has been undertaken as part of the research programme of the United Nations Economic and Social Commission for Asia and the Pacific (ESCAP) on promoting regional economic cooperation and integration, focuses on the China-Central Asia Corridor (China, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan), giving attention to the sub-region’s specific challenges, namely limited international transit opportunities and an increase in bandwidth requirements that is expected to grow exponentially, as the fourth industrial evolution centered on automation and artificial intelligence gathers momentum. The sub-region is characterized as highly dependent on the ease and costs of connecting to neighboring countries for transit, as many countries in the sub-region are landlocked developing countries (LLDC). Because of the geographical features and other factors, the development potential of Central Asia and its integration into globalization, continues to be stymied by insufficient international bandwidth and high transit costs to access international links. Therefore, improved ICT connectivity in Central Asia through the BRI corridor could result in improved availability and affordability of broadband networks and services in the sub-region.

For the purpose of this study, a gap analysis is the methodology that underpins the proposed topology for the China-Central Asia Corridor. The analysis included examining the current state of the optic infrastructure, such as existing and planned fiber-optic networks, existing Internet Exchange Points (IXPs) and international gateways. The study also identifies the key factors that determine the desired future state of infrastructure deployment for the BRI initiative. A topology that consists of connecting Almaty (Kazakhstan) and Urumqi (China), as core nodes, is proposed based on a partial mesh topology. Over and above this core finding, the study concludes that digital infrastructure connectivity has a tendency of lagging behind the rapid opportunities evolving, and the study therefore advocates for sub-regional and regional approaches, including the BRI and Asia-Pacific Information Superhighway (AP-IS) in further expanding regional broadband networks. A key recommendation of the study is co-deployment of broadband infrastructure along passive infrastructure, as an additional cost effective means of achieving fast and affordable broadband connectivity for all.

The provided material presents a priority article on the scientific discovery titled “The phenomenon of simultaneous destruction of water-oil and oil-water emulsions”. The authors propose the corresponding formula: the previously unknown phenomenon of simultaneous destruction of water-oil and oil-water emulsions occurs when polynanostructured surfactant demulsifiers with characteristics akin to crystalline liquids, intramolecular interblock activity, and enduring intramolecular nanomotors (such as block copolymers of ethylene and propylene oxides, which act as sources of oligomer homologues of oxyethylene ethers) are added to crude oil during primary oil processing. This phenomenon is attributed to the redistribution of oligomer homologues, with the most hydrophobic oxyethylene ethers being dispersed in water-oil emulsions and the most hydrophilic ones in oil-water emulsions, resulting in robust nanodispersed phases with crystalline liquid properties.

Heat removal has become an increasingly crucial issue for microelectronic chips due to increasingly high speed and high performance. One solution is to increase the thermal conductivity of the corresponding dielectrics. However, traditional approach to adding solid heat conductive nanoparticles to polymer dielectrics led to a significant weight increase. Here we propose a dielectric polymer filled with heat conductive hollow nanoparticles to mitigate the weight gain. Our mesoscale simulation of heat conduction through this dielectric polymer composite microstructure using the phase-field spectral iterative perturbation method demonstrates the simultaneous achievement of enhanced effective thermal conductivity and the low density. It is shown that additional heat conductivity enhancement can be achieved by wrapping the hollow nanoparticles with graphene layers. The underlying mesoscale mechanism of such a microstructure design and the quantitative effect of interfacial thermal resistance will be discussed. This work is expected to stimulate future efforts to develop light-weight thermal conductive polymer nanocomposites.

This exploratory study aims to identify the main characteristics and relationships between artificial intelligence (AI) and broadband development in Asia and the Pacific. Broadband networks are the foundation and prerequisite for the development of AI. But what types of broadband networks would be conducive are not adequately discussed so far. Furthermore, in addition to broadband networks, other factors, such as income level, broadband quality, and investment, are expected to influence the uptake of AI in the region. The findings are synthesized into a set of policy recommendations at the end of the article, which highlights the need for regional cooperation through an initiative, such as the Asia-Pacific Information Superhighway (AP-IS). 

Disease epidemics may spread quickly and easily throughout nations and continents in our current global environment, having a devastating effect on public health and the world economy. There are over 513 million people worldwide who have been infected, and more than 6.2 million have died due to SARS-CoV-2. There are treatments but no cures for most viruses. Nevertheless, the spread of viruses can be limited by introducing antiviral coatings on public area surfaces and personal protective equipment (e.g., face masks). This work aims to fabricate a polymer-based coating with acrylic resin as a binder that possesses great antiviral activity against the Feline coronavirus (FCov). The chosen polymer, polyethylene glycol (PEG), is used as an antiviral agent because it contains “green” chemistry benefits such as non-toxicity, being inexpensive, readily recyclable, safe, natural, non-flammable, biocompatible, and biodegradable. The PEG/acrylic coating systems of different weight percentages were coated on the glass substrates by the spray-coating method and cured at room temperature for 24 hours. The developed PEG/acrylic coating system that contains 20 wt% of PEG exhibits the highest anti-viral activities (99.9% against FCov) compared to the other weight percentages. From this study, it has been observed that the hydrophilicity of the coating plays an important role in its antiviral activity. The developed coating has a hydrophilic property, in which the contact angle was measured at 83.28 ± 0.5°. The FTIR reveals that there are no existing toxic components or new components contained in the coating samples.