Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

The CO₂  heat pump air conditioning system of new energy vehicle is designed, and the vehicle model of CO₂  heat pump module and heat management system is established based on KULI simulation. The effects of refrigerant charge, running time and compressor speed on the heat pump air conditioning system is studied, and the energy consumption is compared with the PTC heating system and the CO₂ heat pump air conditioning system without waste heat recovery. The results show that the optimal charge for full-service operation is 750 g; increasing the compressor speed can increase the cooling capacity, so that the refrigerant temperature in the passenger compartment and battery inlet can quickly reach the appropriate temperature, but the COP_h, COP_c are reduced by 2.5% and 1.8% respectively. By comparing it with PTC heating and CO₂ heat pump air conditioning systems without waste heat recovery, it is found that the energy consumption of this system is only for the PTC heating systems 42.5%, without waste heat recovery carbon dioxide heat pump air conditioning system of 86.6%. It greatly saves energy, but also increased the waste heat recovery function, so that the system supply air temperature increased by 26%, improve passenger cabin comfort. This  provides a reference for the future experimental research of CO₂ heat pump air conditioning and heat management system. 

Aiming at the problem of road network multi-scale matching, a multi-scale road matching method under the constraint of road mesh of small-scale data has been proposed. First, two road meshes with different scale data are constructed; Secondly, under the constraint of the small-scale road mesh, the composite mesh composed of several road meshes in the large-scale road is extracted, and the mesh matching with the small-scale road mesh is completed; Then, many-to-many matching of road meshes with different scales is realized; finally, the matching relationship between composite mesh and small-scale road mesh is transformed into the matching between multi-scale road mesh boundary roads and internal roads, and the matching of the whole road network is completed. The experimental results show that this method can better realize the matching of multi-scale road network.

Based on the collective forest with common use rights, the social-ecological system analysis framework and autonomous governance theory proposed by Elinor Ostrom are introduced in the forest eco-economic system to analyze the interaction logic among the first-level subsystems and the secondary variables of the forest eco-economic system and the variables related to the autonomous governance of the system to explore the synergistic mechanisms affecting the forest eco-economic system. The results show that: in the case of information asymmetry, collective actions of governmental and non-governmental organizations will aggravate the dilemma of forest eco-economic synergistic development; actors extract forest resource units from the forest resource system to achieve economic benefits; and renewable resources of forest ecosystems can be sustained in the long term when the average extraction rate of humans from forest ecosystems does not exceed the average replenishment rate.