Projects implemented under life cycle contracts have become increasingly common in recent years to ensure the quality of construction and maintenance of energy infrastructure facilities. A key parameter for energy facility construction projects implemented under life cycle contracts is their duration and deadlines. Therefore, the systematic identification, monitoring, and comprehensive assessment of risks affecting the timing of work on the design and construction is an urgent practical task. The purpose of this work is to study the strength of the influence of various risks on the duration of a project implemented on the terms of a life cycle contract. The use of the expert assessment method allows for identifying the most likely risks for the design and construction phases, as well as determining the ranges of deviations from the baseline indicator. Using the obtained expert evaluations, a model reflecting the range and the most probable duration of the design and construction works under the influence of risk events was built by the Monte-Carlo statistical method. The results obtained allow monitoring and promptly detecting deviations in the actual duration of work from the basic deadlines set in the life cycle contract. This will give an opportunity to accurately respond to emerging risks and build a mutually beneficial relationship between the parties to life cycle contracts.

Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

The purpose of this study is to examine the experiences of project managers working in the distinct environment of clinical trial organizations as project management changes in dynamic labor markets. The literature emphasizes the changing skill set needed for project managers and stresses the value of cognitive flexibility, interpersonal skills, and lifelong learning. Nonetheless, there is still a great deal to learn about how these dynamics appear in the setting of clinical trial organizations. By investigating project managers’ perspectives and involvement in lifetime learning and skill development inside clinical trial organizations, this study seeks to close this gap. To elucidate the nuances of their professional experiences, 64 project managers were interviewed using a qualitative methodology. Key themes emerged from the thematic analysis, including the importance of interpersonal and personal qualities, the dynamic nature of abilities like creativity and critical thinking, and the strategic application of lifelong learning. The findings add new evidence to the body of knowledge by offering a sector-specific understanding of the lifelong learning needs and skill requirements for project managers in clinical trial organizations. The study emphasizes how crucial it is to continuously learn to improve healthcare outcomes and adjust to industry-specific problems. Contextual implications encompass perspectives for entities seeking to maximize training regimens and augment the flexibility of project management groups in clinical trial environments. This work advances theoretical ideas and practical concerns for lifelong learning and skill development in clinical trial organizations. It also adds subtle insights into a specialized domain to the discourse on project management.

In Emerging economies, MNCs (Multinational corporations) encounter several issues while devising Strategies to penetrate foreign markets, examining these SMEs’ performance in present times and assessing their internationalisation process is crucial. The purpose of this research is to investigate how international entrepreneurial orientation affects SMEs’ international performance during internationalization, as well as how organizational culture in the Kingdom influences the international performance of these MNCs. To attain this objective (n = 206) MNCs in the Kingdom have adopted internationalisation strategies. Questionnaires were administered as part of a survey approach for this study. To forecast and estimate relationships, partial least squares structural equation modelling (PLS-SEM) was employed. This study indicates that improving internationalization performance, mainly through active participation in foreign markets, is one of the SMEs’ strategies during the internationalization process. The empirical findings demonstrate that international entrepreneurial orientation influences the internationalisation performance of SMEs largely influenced by organisational culture. Previous research shows that the success of SMEs’ internationalization, however, is not directly impacted by their international entrepreneurial orientation. This study supports the significance of organisational culture during internationalisation. This study offers insightful information that motivates policymakers and owner-managers in developing nations, especially in KSA, to build organizational cultures and dynamic capacities that meet the demands of globalization in today’s business scenario.